The effect of 2-oxoindoline-3-glyoxylic acid derivatives on animals’ behavioral and autonomic reactions in the open field test
Ескіз недоступний
Дата
2023
Назва журналу
Номер ISSN
Назва тому
Видавець
Taylor & Francis
Анотація
Screening research on the effect of 2-oxoindoline-3-glyoxylic acid derivatives
on the emotional and behavioral responses of rats in the open field test was
performed. 2-oxoindoline derivatives were suspended in the injection water
using the Tween-80 emulsifier (one drop with 25 mg of test substance) and
intraperitoneally administered at a dose of 12 mg/kg 1 hour before the first
test. Diazepam was administered in the dosage of 2 mg/kg and in the same
way as the investigated compounds. Neuroethological indicators have been
studied including the latent period of the first movement, ambulation (horizontal
activity), number of upright postures (vertical activity), the number of
times animals moved to the center, autonomic balance indicators such as the
number of grooming acts and defecation acts calculated by the number of
fecal balls (boluses). It was found that most 2-oxoindoline derivatives suppressed
or did not affect animals’ orienting and investigatory responses in
the open field test. Under these conditions, the compounds suppressed emotionality
manifested as a reduced number of fecal balls and grooming acts
indicating a decrease in anxiety and fear in a stressful situation caused by the
novelty of the open field test. Based on the analysis, it can be argued that
2-oxoindoline derivatives can modify the psychophysiological features of
intact rats, i.e. their neuropsychotropic properties.
Опис
Ключові слова
2-oxoindoline-3-glyoxylic acid derivatives, open field test, rat
Бібліографічний опис
The effect of 2-oxoindoline-3-glyoxylic acid derivatives on animals’ behavioral and autonomic reactions in the open field test / R. V. Lutsenko, O. V. Storozhenko, A. H. Sydorenko, S. Yu. Chechotina, O. A. Lutsenko // Egyptian Journal of Basic and Applied Sciences. – 2023. – Vol. 10, № 1. – P. 537–544.