The influence of activity of systemic inflammatory process, leptin and adiponectin levels on insulin resistance development and atherosclerotic affections in patients with rheumatoid arthritis

Abstract

The obtained data testify patients with rheumatoid arthritis (RA) without metabolic syndrome (MS) have higher level of adipokins compared with the patients of control group. There is statisticaly reliable correlation between the level of systemic inflammation and insulin resistance in patients with rheumatoid arthritis. This fact has proved the presence of systemic inflammation influence on the development of insulin resistance in patients with rheumatoid arthritis. There are correlations between the insulin resistance level and lipid metabolic disorders, the thickness of carotid intima-media (IM) complex, and the level of endothelium-dependent (EDVD) and nonendothelium-dependent vasodilatation (NEDVD). These above mentioned correlations prave the prevailing influence of insulin resistance on the development of atherosclerotic vascular affections in patients with rheumatoid arthritis.