Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of Salmonella typhi
Ескіз недоступний
Дата
2019
Назва журналу
Номер ISSN
Назва тому
Видавець
Wydawnictwo Aluna
Анотація
There has been demonstrated that pharmaceutical effect of epigallocatechin-3-gallate (EGCG), a polyphenol, which is found in green tea (Camellia sinensis), is implemented through the activation of Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2).The importance of Keap1 / Nrf2 / antioxidant response element (ARE) system is
determined by the fact that the state of NF-κB- and АР-1-associated pathways depends on its activity. Recent studies have demonstrated the property of quercetin to suppress ubiquitin-dependent proteolysis of complex of NF-κB and its inhibitory protein IκB. All this provides preconditions to eliminate the potentiality of NF-κB-dependent expression of the number of genes of pro-oxidant and pro-inflammatory proteins. However, co-effect produced by quercetin and EGCG on the oxidative nitrosative stress markers in the periodontal tissues is still unclear.
Опис
Ключові слова
signal pathway Keap1 / Nrf2 / ARE, periodontium, epigallocatechin-3-gallate, quercetin, lipopolysaccharide-induced systemic inflammatory response, oxidative-nitrosative stress
Бібліографічний опис
Yelins’ka A. M. Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of Salmonella typhi / A. M. Yelins’ka, L. I. Liashenko, V. O. Kostenko // Wiadomości Lekarskie. – 2019. – T. LXXII, № 8. – P. 1499–1503.