Світ медицини та біології, 2023, № 1 (83)

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https://repository.pdmu.edu.ua/handle/123456789/20382

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Перегляд Світ медицини та біології, 2023, № 1 (83) за Автор "Kaydashev, I. P."

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    Correlation analysis of circadian rhythm with severity of psoriasis and obesity
    (Полтавський державний медичний університет, 2023) Yemchenko, Y. O. ; Kaydashev, I. P.; Ischeykin, K. Ye.; Bezeha, O. V.; Vasylyeva, K. V.; Oliinichenko, Ya. O.; Morokhovets, H. Yu.; Ємченко, Яна Олександрівна; Кайдашев, Ігор Петрович; Іщейкін, Костянтин Євгенович; Безега, Олена Вікторівна; Васильєва, Катерина Володимирівна; Олійніченко, Ярина Олександрівна; Мороховець, Галина Юріївна
    The recent increase in cases of comorbidity of psoriasis and obesity leads to severe, atypical, disabling, and therapyresistant forms of dermatosis, significantly worsen the quality of life of patients, reduces work capacity and social activity of patients, which determines not only the medical but also the social significance of the problem. There is a theoretical rationale for the possible role of circadian rhythm disturbances, manifested by a change in eating behavior, a decrease in sleep duration, and the individual chronotype of patients in developing obesity and some autoimmune diseases. However, this issue remains insufficiently studied and proven. The purpose of our study was to identify the correlation between the circadian rhythm and indicators of changes in the chronotype of a person's working capacity and indicators of the severity of the course of psoriatic disease, the degree of obesity, and the degree of the negative impact of the disease on the quality of life of patients. The results of the correlation analysis showed a very high negative correlation between the chronotype of patients' working capacity and BMI indicators and a high negative correlation between the indicators of the PASI index, ACTIVITY, and the chronotype of patients' working capacity.
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    Документ
    Research on the relationship between the severity of the course of psoriasis and metabolic syndrome and the level of indicators of systemic inflammation
    (Полтавський державний медичний університет, 2023) Yemchenko, Y. O.; Kaydashev, I. P.; Ishcheykin, K. Ye.; Bezeha, O. V.; Ємченко, Яна Олександрівна; Кайдашев, Ігор Петрович; Іщейкін, Костянтин Євгенович; Безега, Олена Вікторівна
    In patients with moderate psoriasis with concomitant metabolic syndrome, the indicators of general clinical and biochemical blood tests and carbohydrate and lipid metabolism were determined, and indicators of systemic inflammation were assessed by the level of susceptible C-reactive protein, ceruloplasmin, interleukin-6 and tumor necrosis factor-α. A laboratory study found that in patients with moderate psoriasis with concomitant metabolic syndrome, an important role is played by the systemic inflammatory process, which is accompanied by the development of insulin resistance, impaired lipid and nitrogen metabolism, and regulation of vascular tone. Furthermore, an increase in the intensity of systemic inflammation is accompanied by an increase in skin lesions, an increase in systolic blood pressure, and a violation of lipid and carbohydrate metabolism.