Світ медицини та біології. 2023

Постійне посилання на фонд

https://repository.pdmu.edu.ua/handle/123456789/20379

Переглянути

Зараз показуємо 1 - 20 з 37

Correlation analysis of circadian rhythm with severity of psoriasis and obesity
(Полтавський державний медичний університет, 2023) Yemchenko, Y. O. ; Kaydashev, I. P.; Ischeykin, K. Ye.; Bezeha, O. V.; Vasylyeva, K. V.; Oliinichenko, Ya. O.; Morokhovets, H. Yu.; Ємченко, Яна Олександрівна; Кайдашев, Ігор Петрович; Іщейкін, Костянтин Євгенович; Безега, Олена Вікторівна; Васильєва, Катерина Володимирівна; Олійніченко, Ярина Олександрівна; Мороховець, Галина Юріївна
The recent increase in cases of comorbidity of psoriasis and obesity leads to severe, atypical, disabling, and therapyresistant forms of dermatosis, significantly worsen the quality of life of patients, reduces work capacity and social activity of patients, which determines not only the medical but also the social significance of the problem. There is a theoretical rationale for the possible role of circadian rhythm disturbances, manifested by a change in eating behavior, a decrease in sleep duration, and the individual chronotype of patients in developing obesity and some autoimmune diseases. However, this issue remains insufficiently studied and proven. The purpose of our study was to identify the correlation between the circadian rhythm and indicators of changes in the chronotype of a person's working capacity and indicators of the severity of the course of psoriatic disease, the degree of obesity, and the degree of the negative impact of the disease on the quality of life of patients. The results of the correlation analysis showed a very high negative correlation between the chronotype of patients' working capacity and BMI indicators and a high negative correlation between the indicators of the PASI index, ACTIVITY, and the chronotype of patients' working capacity.
Differences in psychological adaptation, predictors and features of psychological and social maladjustment formation in foreign students of medical institutions of higher education in Ukraine
(Полтавський державний медичний університет, 2023) Borysenko, V. V.; Herasymenko, L. O.; Isakov, R. I.; Fysun, Yu. O.; Kydon, P. V.; Shynder, V. V.; Kazakov, O. A.; Борисенко, Володимир Васильович; Герасименко, Лариса Олександрівна; Ісаков, Рустам Ісроїлович; Фисун, Юрій Олександрович; Кидонь, Павло Володимирович; Шиндер, Вячеслав Володимирович; Казаков, Олексій Анатолійович
The psychological adaptation of international students to a Ukrainian higher medical school depends on individual and group factors, motivational and background characteristics, cognitive, information-cognitive and gnostic factors, interpersonal relations in international study groups, and the formation of psychosocial maladaptation in foreign students indicates the need to create forms and methods of a differentiated approach to the personality of each student. The study describes the psychological differences in adaptive mechanisms among international students, the presence and severity of psychosocial maladjustment in various areas, and the factors shaping its development. It is shown that the education of international students in medical higher education institutions contributes to integrating domestic medical schools into the global intellectual space and, therefore, stimulates the development of medical science and practice in the country.
Metrical indices of the cecum wall in areas of gut-associated lymphoid tissuelocalisation under the in influence of food additive complex
(Полтавський державний медичний університет, 2023) Kinash, O. V.; Yeroshenko, G. A.; Shevchenko, K. V.; Slipchenko, L. B.; Vatsenko, A. V.; Riabushko, O. B.; Marchenko, S. P.; Кінаш, Оксана В'ячеславівна; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Сліпченко, Лариса Борисівна; Ваценко, Анжела Володимирівна; Рябушко, Олена Борисівна; Марченко, С. П.
There are insufficient data in the current literature on the effect of food additives on the occurrence of pathological processes in the intestine. A total of 84 sexually mature male non-linear rats were used in the experiment. Rats of the control group consumed drinking water and received oral physiological solution. Animals in the experimental group received food additives at the following doses: sodium nitrite (E250) 0.6 mg/kg, sodium glutamate (E621) 20 mg/kg, ponceau 4R (E124) 5 mg/kg. Sampling for histological examination was carried out at 1, 4, 8, 12 and 16 weeks. A significant reduction in the thickness of the cecum wall of the animals in the areas of localisation of intestinal-associated lymphoid tissue was found at the early stages of observation. A marked lymphoid tissue reaction in the form of intense cellular infiltration of the submucosa and mucosa was recorded. Disturbance of crypt structure and desquamation of epithelium occurred. At the late terms of observation there was a significant increase of the cecum wall thickness in the areas of localization of the lymphoid tissue associated with the intestine due to edema of submucosa,partial restoration of mucosa structures.
Methacrylic acid ether-related changes in the intensity of marking of components of the rat hard palate mucosa revealed by probing with sialo-specific SNA lectin from the bark of sambucus nigra
(Полтавський державний медичний університет, 2023) Tymoshenko, Yu. V.; Yeroshenko, G. A.; Kulai, О. O.; Ryabushko, O. B. ; Shevchenko, K. V.; Ulanovska-Tsyba, N. А.; Stotska, L. V.; Тимошенко, Юлія Володимирівна; Єрошенко, Галина Анатоліївна; Кулай, Ольга Олександрівна; Рябушко, Олена Борисівна; Шевченко, Костянтин Васильович; Улановська-Циба, Наталія Аркадіївна; Стоцька, Л. В.
The decrease in secretory activity of the salivary glands disrupts local homeostasis in the oral cavity, affects the functioning of the entire digestive system, inhibits processes of physiological regeneration and impairs the protective properties of the mucous membrane against antigens. We have found changes in the morphofunctional state of the hard palate mucosa during the experimental hyposalivation using lectin probing method.
Anxiety, depression, dysfunction of the autonomic nervous systemAnd their correlations during COVID-19 pandemic
(Полтавський державний медичний університет, 2023) Zaporozhets, T. M.; Korovina, L. D.; Sukhomlyn, T. A.; Mishchenko, I. V.; Sukhomlyn, A. A.; Запорожець, Тетяна Миколаївна; Коровіна, Лідія Дмитрівна; Сухомлин, Тетяна Анатоліївна; Міщенко, Ігор Віталійович; Сухомлин, Андрій Анатолійович
Метою дослідження було вивчення взаємозв'язку психологічних і регуляторних механізмів розвитку дисфункції автономної нервової системи у відповідь на стресові фактори під час пандемії COVID-19. Було обстежено 133 студента. Використовували опитувальники HADS, PSS-10, State-aR. Дисфункцію автономної нервової системи визначали за А.М. Вейном та на основі аналізу варіабельності серцевого ритму. Серед когорти обстежених у 37,0 % відмічались прояви тривоги та 38,1 % мали субклінічні та клінічні прояви депресії. Помірний та високий рівень суб'єктивного стресу мали 99,1 % опитаних. У осіб з субклінічними та клінічними ознаками депресії відзначалась змінена варіабельність серцевого ритму. Прямі зв’язки були між рівнями тривоги та депресії (R=0,50, p<0,001), тривоги та стресу (R=0,28, p<0,01), тривоги та показника дисфункції АНС (R=0,23, p<0,05), депресії та дисфункції АНС (R=0,30, p<0,005), зворотні – між рівнем тривоги та сумарного показника автономної регуляції aR (R=–0,45, p<0,001), між рівнем депресії та сумарного показника автономної регуляції aR (R=–0,29, p<0,01).
Characteristics of disorders of the quality of life of young patients depending on the variant of the course of gastroesophageal reflux disease
(Полтавський державний медичний університет, 2023) Gorodnytska, I. M.; Skrypnyk, I. M.; Maslova, G. S.; Городницька, Інеса Михайлівна; Скрипник, Ігор Миколайович; Маслова, Ганна Сергіївна
The article represents the results of our research on determining the influence of esophageal symptoms of erosive and non-erosive forms of gastroesophageal reflux disease on indicators of the physical and mental components of quality of life according to the Medical Outcomes Study Questionnaire Short-Form 36. The presence and degree of severity of symptoms of gastroesophageal reflux disease were analyzed using the Gastroesophageal Reflux scale Disease Questionnaire. We examined 18 patients with an erosive form and 18 patients with a non-erosive form of gastroesophageal reflux disease. It is shown that against the background of the erosive form of gastroesophageal reflux disease, daily manifestations of the symptoms of the disease are more often observed, namely heartburn (RR=6.00 (0.80-44.95); p>0.05), regurgitation and pain in the epigastric region of the abdomen (RR=2.50 (0.56-11.25); p>0.05), which leads to violations of mainly physical components of quality of life. At the same time, the esophageal symptoms of the non-erosive form of gastroesophageal reflux disease change the quality of life of patients in categories that characterize mental health.
Dependence of the course of odontogenic phlegmons of maxillofacial localization on circadian rhythms
(Полтавський державний медичний університет, 2023) Lychman, V. O.; Lokes, K. P.; Steblovskyi, D. V.; Ivanytska, O. S.; Bukhanchenko, O. P.; Stavytskyi, S. O.; Avetikov, D. S.; Личман, Віталій Олександрович; Локес, Катерина Петрівна; Стебловський, Дмитро Валерійович; Іваницька, Олена Сергіївна; Буханченко, Ольга Петрівна; Ставицький, Станіслав Олександрович; Аветіков, Давид Соломонович
У розвитку одонтогенних флегмон значну роль відіграє мікрофлора, загальні та місцеві захисні фактори організму, анатомо-топографічні особливості щелепно-лицевої ділянки. Пацієнтам, на тлі стандартної терапії, призначали внутрішньовенне введення кріоконсервованого екстракту плаценти у поєднанні з місцевим застосуванням цього препарату у складі мазі на основі Хлорамфенікола та Метилурацила. Хронотип пацієнта визначали за опитувальником Горна-Остберга. Серед показників загального стану пацієнтів показник П-1,3 на 3-тю добу знизився на 0,47 % , на 67,8 % на 5 ту добу – на 0,83 % на 83,7 % незалежно від хронотипу хворого. Серед показників локальних змін у рані найбільш достовірне зниження зафіксовано за показником Р-2,2: на 1,52 %±0,17 % на 5 добу після операції у 83,0 % хворих ранкового хронотипу, оперованих в ранок.
Restructuring of the rat pulmonary vascular bed induced by the conplex of food additives
(Полтавський державний медичний університет, 2023) Yeroshenko, G. A.; Donets, I. M.; Shevchenko, K. V.; Ulanovska-Tsyba, N. A.; Grygorenko, A. S.; Sokolenko, V. M.; Sharlay, N. M.; Єрошенко, Галина Анатоліївна; Донець, Ілона Миколаївна; Шевченко, Костянтин Васильович; Улановська-Циба, Наталія Аркадіївна; Григоренко, Альона Сергіївна; Соколенко, Валентина Миколаївна; Шарлай, Наталія Миколаївна
The paper presents the results of a morphometric study of the vessels’ lumen diameter of the large circulatory circle, as well as the vessels of the small circulatory circle of the rats’ lungs of under the complex effect of food additives. It was established that the use of a complex of food additives leads to a change in morphometric indicators, and in the early stages it was accompanied by spastic reactions of small circulatory circle pulmonary vessels and vessels of the microcirculatory of the large blood circulation, which was confirmed by a decrease in morphometric indicators of the lumen diameter. During the following periods of study, the vessels of the hemomicrocirculatory channel of the large circulatory circle responded by increasing the average values of morphometric indicators, and of all its links, as a result of the long-term action, first of all, of sodium nitrite on the smooth myocytes of the vessels of the resistive link and the action of compensatory and restorative mechanisms in response to an increase in pulmonary pressure vessels of the small blood circulation to the vessels of the exchange and capacitive links of the large blood circulation. At the end of the experiment, the morphometric indicators did not fully recover, the vessels of the large circulatory circle remained in a decompensated state, which was expressed by an increase in the average values of the morphometric indicators of the diameter of the lumen of the vessels.
The influence of stimulation of organism with bacterial lipopolysaccharide on the background of metabolic syndrome modeling on the development of oxidative stress in rat heart
(Полтавський державний медичний університет, 2023) Akimov, O. Y.; Mykytenko, A. O.; Kostenko, V. O.; Yeroshenko, G. A.; Акімов, Олег Євгенович; Микитенко, Андрій Олегович; Костенко, Віталій Олександрович; Єрошенко, Галина Анатоліївна
Metabolic syndrome is one of the most widespread non-infectious pathologies in the world affecting almost a quarter of world population. The purpose of this work is to determine the activity of antioxidant enzymes, the production of superoxide anion radical, the content of oxidatively modified proteins and the concentration of malondialdehyde in the heart of rats under conditions of experimental metabolic syndrome and stimulation of the organism with bacterial lipopolysaccharide. In the test group of animals superoxide production increased by 6.31 times, activity of superoxide dismutase decreased by 2.97 times, the activity of catalase decreased by 2.4 times, the concentration of malondialdehyde increased by 3.08 times, and the content of oxidatively modified proteins increased by 2.81 times. Stimulation of organism with bacterial lipopolysaccharide on the background of induction of metabolic syndrome by high fructose diet shows synergetic effect on increase of reactive oxygen species production, severely decreases activity of antioxidant enzymes and intensifies oxidative damage to protein and lipid structures of rat heart.
Thiazolidinediones in the treatment of psoriasis in patients with obesity
(Полтавський державний медичний університет, 2023) Yemchenko, Ya. O.; Kaydashev, I. P.; Ischeykin, K. Ye.; Bezeha, O. V.; Vasylyeva, K. V.; Oliinichenko, Ya. O.; Bolotna, L. A.; Ємченко, Яна Олександрівна; Кайдашев, Ігор Петрович; Іщейкін, Костянтин Євгенович; Безега, Олена Вікторівна; Васильєва, Катерина Володимирівна; Олійніченко, Ярина Олександрівна; Болотна, Людмила Анатоліївна
Psoriasis is the most common chronic, genetically determined autoimmune polyetiologic inflammatory disease with impaired epidermal proliferation, provoked by exogenous and endogenous factors and manifested by erythematous scaly elements, papules and plaques. Despite the widespread prevalence of psoriasis and a large number of studies on this problem, there is still no single view of the pathogenesis of this dermatosis. For an objective understanding of the pathogenesis of psoriasis, it is necessary to consider the insufficiently studied comorbidity of this pathology. Recently, an undeniable link between psoriasis and obesity has been proven. Taking into account the current data on the role of systemic inflammation underlying the development of both psoriasis and obesity, the study of molecular mechanisms of its development, and taking into account the role of proinflammatory nuclear transcription factors, thiazolidinediones are the pathogenetically determined drug of choice for the treatment of these diseases. In this study, we determined the efficacy of using 45 mg of pioglitazone once daily for six months in the complex treatment of patients with moderate vulgar psoriasis with concomitant alimentary obesity of I-II degree by clinical and immunological studies of systemic inflammation. Analyzing the study results, it was found that long-term use of 45 mg of pioglitazone was effective, led to a decrease in systemic inflammation, and contributed to a milder course of psoriasis in case of recurrent relapse of the disease.
Formation of optimal scar on the background of surgical treatment of maxillofacial diseases of different origins
(Полтавський державний медичний університет, 2023) Lokes, K. P.; Voloshyna, L. I.; Ivanytska, O. S.; Yatsenko, I. V.; Gavriliev, V. M.; Rozkolupa, O. O.; Avetikov, D. S.; Локес, Катерина Петрівна; Волошина, Людмила Іванівна; Іваницька, Олена Сергіївна; Яценко, Ігор Володленович; Гаврильєв, Віктор Миколайович; Розколупа, Олександр Олексійович; Аветіков, Давид Соломонович
Концепція «оптимального рубця» має значний вплив на планування та проведення хірургічного лікування пацієнтів із захворюваннями щелепно-лицевої локалізації різноманітного походження, а також обумовлює напрямок розвитку проведення хірургічного лікування. Проведено ретроспективний аналіз журналів стаціонарного лікування, історій хвороби та звітів про роботу щелепно-лицевого відділення Полтавської обласної клінічної лікарні за 2021 та 2022 роки. Хірургічні втручання частіше проводили позаротовим методом, який забезпечує найкоротший шлях до гнійного осередку, але без урахування особливостей деформації та розслаблення непошкодженої шкіри цих ділянок. Найбільшого поширення набув піднижньощелепний доступ. Суттєвий вплив на стадію та якість формування післяопераційного рубця має механізм загоєння операційної рани, що утворюється на тлі бактеріального обсіменіння, що визначається типом хірургічної патології.
Dynamics of local immunological indicators accompanied by different types of reactivity of the organism
(Полтавський державний медичний університет, 2023) Yarov, Yu. Yu.; Silenko, Yu. I.; Yeroshenko, G. A.; Shevchenko, K. V.; Grygorenko, A. S.; Яров, Юрій Юрійович; Силенко, Юрій Іванович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Григоренко, Альона Сергіївна
The dynamics of local immunity in the oral fluid in patients with generalized periodontitis after surgery accompanied by normo-, hyper- and hyporeactivity of the body. It was revealed that tension of local (lysozyme,-lysine, SIgA, IgA, IgG in the oral fluid) immunity with normalization by the end of observation is typical for patients with generalized periodontitis withnormoreactivity of the body after surgery. In case of hyperreactivity the dysfunction of local immunity which is shown by the expressed fluctuations of level of lysozyme, -lysine, secretory IgA, IgA and IgG in oral fluid with their imbalance by the end of supervision is defined. In case of hyporeactivity dysfunction of local immunity is observed that is shown by a later rise and rather low amplitude of changes of the investigated parameters.
Characteristics of structural components of intrahepatic biliary tracts in humans
(Полтавський державний медичний університет, 2023) Dubinin, D. S.; Shepitko, V. I.; Dubinin, S. I.; Stetsuk, Ye. V.; Boruta, N. V.; Levchenko, O. A.; Ulanovska-Tsyba, N. A.; Дубінін, Дмитро Сергійович; Шепітько, Володимир Іванович; Дубінін, Сергій Іванович; Стецук, Євген Валерійович; Борута, Наталія Володимирівна; Левченко, Ольга Анатоліївна; Улановська-Циба, Наталія Аркадіївна
Among the most common diseases of the hepatobiliary system are chronic cholecystitis, cholangitis, gallstone disease, and post-cholecystectomy syndrome, which are increasingly prevalent. Gallstone disease affects more than 10 % of the adult population in various countries around the world. There is a doubling of the number of patients every ten years in all economically developed countries. This pathology is found in women 3-4 times more often than in men. The incidence of the disease increases with age. The intrahepatic bile ducts of humans consist of two layers: an outer adventitial layer and an inner mucosal layer. In the initial part of the liver's biliary system, the biliary pathways in the mucous membrane are composed of cuboidal epithelium resting on the basal membrane. In the middle section of the human biliary system, not only cuboidal but also columnar epithelial cells appear. In the terminal section of the biliary system, the number of columnar epithelial cells in the inner lining increases. Epithelial cells change their shape from cuboidal to columnar. The outer layer is composed of loose connective tissue, with fibroblastic cell rows and an intercellular substance containing collagen fibers and amorphous material.
Rhythm control in patients with bradyasystolic atrial fibrillation
(Полтавський державний медичний університет, 2023) Miakinkova, L. O.; Liulka, Ye. M.; Katerenchuk, I. P.; Teslenko, Y. V.; Pysana, B. O.; М'якінькова, Людмила Олександрівна; Люлька, Євген Миколайович; Катеренчук, Іван Петрович; Тесленко, Юрій Віталійович; Писана, Богдана Олександрівна
Atrial fibrillation is the most common cardiac arrhythmia associated with thromboembolism, heart failure, depression, deterioration of quality of life, and reduced physical endurance. The rhythm control strategy is considered optimal in its treatment but is not always achievable. Right ventricular endocardial pacing is recommended for patients with bradycardic atrial fibrillation and preserved ejection fraction but can cause ventricular dyssynchrony. The aim of the study was to evaluate the effectiveness of implanting a dual-chamber pacemaker as an alternative method for sinus rhythm control in patients with long-standing bradysystolic atrial fibrillation and preserved ejection fraction, compared with single-chamber right ventricular pacing. Diastolic function, left atrial volume index, exercise tolerance, and quality of life were studied. Dual-chamber pacing is effective in rhythm control, and the severity of symptoms is reduced. Compared with single-chamber right ventricular pacing, there were decreased left atrial volume, tricuspid regurgitation rate, natriuretic peptide levels, increased exercise tolerance, improved quality of life indices, and reduced anxiety and depression. Key words: atrial fibrillation, heart
Remodeling of the wall of the ascending colon in rats under the influence of the food additives complex
(Полтавський державний медичний університет, 2023) Kinash, O. V.; Yeroshenko, G. A.; Shevchenko, K. V.; Grygorenko, A. S.; Layosh, N. V.; Vatsenko, A. V.; Solod, A. V.; Кінаш, Оксана В'ячеславівна; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Григоренко, Альона Сергіївна; Лайош, Н. В.; Ваценко, Анжела Володимирівна; Солод, Анатолій Вікторович
Food additives are substances added to raw materials, finished products and medicines to extend the shelf life of the product, prevent the development of pathogenic microflora, and improve taste and organoleptic qualities. Monosodium glutamate, sodium nitrite and ponceau 4R are among the most widely used food additives. The experiment involved 84 mature male rats. The animals received 0.6 mg/kg sodium nitrite E250, 20 mg/kg monosodium glutamate E621 and 5 mg/kg ponceau 4R orally. Samples of the ascending colon of rats for histological examination were taken at 1, 4, 8, 12 and 16 weeks. It was found that oral administration of the food additives complex MSG, ponceau 4R and sodium nitrite for 16 weeks causes significant changes in the morphometric parameters of the wall of the ascending colon in rats. A pronounced reaction of the intestinal mucosa is characterized by the destruction of intestinal epithelial cells and disruption of the crypt structure with subsequent incomplete recovery at late follow-up.
Craniotopographic characteristics of venous-liquor relationships in the sagittal plane
(Полтавський державний медичний університет, 2023) Bondarenko, S. V.; Dubyna, S. O. ; Serbin, S. I.; Khapchenkova, D. S.; Koptev, M. M. ; Sovgyria, S. М.; Danylchenko, S. І.; Бондаренко, Станіслав Володимирович; Дубина, Сергій Олександрович; Сербін, Сергій Ігорович; Хапченкова, Дар’я Сергіївна; Коптев, Михайло Миколайович; Совгиря, Світлана Миколаївна; Данильченко, Світлана Іванівна
This study was performed on 100 corpses of people of different ages and gender with the manufacturing of native preparations of the brain with membranes and liquor structures. Of the specified number of morphological objects, 70 preparations of veins and sinuses of the dura mater of the brain and 30 preparations of the cerebrospinal fluid system of the brain of adults were made. We used such research methods as: macro – and micropreparation of anatomical objects of the brain; cranio – and morphometry of veins, sinuses of the dura mater of the brain and liquor structures of the brain; manufacturing of corrosive (acrylic) casts-preparations of veins, sinuses of the dura mater of the brain and liquor formations of the brain; injection technique; variational-statistical analysis of morphometric data; computer-graphic analysis. The craniotopographic (metric) indicators of venous-liquor relationships in the sagittal plane obtained by us can be used to substantiate the insertion of a puncture needle into the cavity of the lateral ventricles or their departments, based on the maximum allowable depth of its insertion.
Morphological changes of corticosterocytes and chromaffin cells after 1 month of chemical castration under conditions of correction with quercetin
(Полтавський державний медичний університет, 2023) Skotarenko, T. A.; Скотаренко, Тетяна Анатоліївна
It is well known that endocrine pathology is a leading disease in the morbidity structure of the Ukrainian population. It is important to study the metabolic effects of hormones of the structural components of the hypothalamic-pituitary-gonadal axis on other peripheral endocrine glands and body organs. Modern research on testosterone proves its effect on the biochemical processes of nervous tissue, liver, organs of the male and female reproductive systems, and others. The paper describes the main morphological changes of corticosterocytes in the adrenal cortex area and endocrinocytes of the adrenal medulla of white rats during the correction of central deprivation of testosterone synthesis during 1 month of the experiment. It was found that the inhibition of testosterone synthesis caused reactive changes in both - corticosterocytes and chromaffin cells, manifested at the microscopic level by the variability of morphometric parameters.
Immunocompetent liver cells reaction to inhibition of luteinizing hormone synthesis on the 180th day
(Полтавський державний медичний університет, 2023) Rud, M. V.; Shepitko, V. I.; Stetsuk, Ye. V.; Sydorenko, A. G.; Voloshyna, O. V.; Starchenko, I. I. ; Nalyvaiko, A. O.; Рудь, Марія Володимирівна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Сидоренко, Антоніна Григорівна; Волошина, Олена Валеріївна; Старченко, Іван Іванович; Наливайко, Андрій Олександрович
Hepatic macrophages play a central role in maintaining liver homeostasis and in the pathogenesis of liver injury. Liver macrophages are composed of functionally distinct cellular subpopulations. Currently, there is interest in the effect of androgens and their receptors on different liver cells and the development of liver pathology as well as the potential impact of quercetin on androgen synthesis inhibition. The blockade of luteinising hormone synthesis by administration of triptorelin acetate on day 180 of the experiment caused morphological changes in the structure of the rat liver, in particular in the cellular, connective tissue and vascular components. Total activity of NO synthases in the liver rose up as well as nitrite concentration. Arginase activity was decreased. Administration of quercetin leads to a decrease in the total activity of NO synthases. The shift in macrophage polarization toward the predominance of M1 may be a consequence of endothelial dysfunction as a result of luteinizing hormone synthesis inhibition.
Quantitative and qualitative changes in red bone marrow monocyte dipherone and microenvironmental cells during long-term triptorelin acetate administration in the experiment
(Полтавський державний медичний університет, 2023) Martynenko, R. V.; Shepitko, V. I.; Pelypenko, L. B.; Boruta, N. V.; Martynenko, V. B.; Vilhova, O. V.; Stetsuk, Y. V.; Мартиненко, Роман Віталійович; Шепітько, Володимир Іванович; Пелипенко, Лариса Борисівна; Борута, Наталія Володимирівна; Мартиненко, Віталій Борисович; Вільхова, Олена Вікторівна; Стецук, Євген Валерійович
States. Huggins and Hodges demonstrated the therapeutic effect of testosterone deficiency in the gonads in the 1940s and thus confirmed the concept that prostate cancer is an androgen-dependent disease. Androgen deprivation therapy (ADT) is the main palliative treatment for men with locally advanced and metastatic prostate cancer, with the goal of reducing testosterone levels to the level obtained by surgical castration. The long-term chemical castration with triptorelin acetate leads to quantitative and qualitative changes in monocytic sprout cells at all levels of differentiation and proliferation with a complementary reaction of microenvironmental cells. The maximum quantitative changes in monocyte cells were observed at the 3rd month of the study, followed by a gradual recovery to the control group. Changes in the microenvironment cells: macrophages and reticular cells, were characterized by a stable reaction in the early stages of the study in the form of a decrease in the number and ratio of NSCs, with subsequent recovery of quantitative and qualitative changes to the level of the control group of animals. The adipocyte reacts at all stages of the study with a steady increase in quantitative and qualitative characteristics.
Relationship between indicators of depression, quality of life, compliance and blood pressure in patients undergoing renal replacement therapy
(Полтавський державний медичний університет, 2023) Rustamian, S. T.; Katerenchuk, I. P.; Yarmola, T. I.; Pustovoyt, H. L.; Tkachenko, L. A.; Ovcharenko, L. K.; Рустамян, Сатєнік Тігранівна; Катеренчук, Іван Петрович; Ярмола, Тетяна Іванівна; Пустовойт, Ганна Леонідівна; Ткаченко, Лідія Афанасіївна; Овчаренко, Людмила Костянтинівна
This article presents the results of the relationship between blood pressure indicators and anxiety and depression, indicators of quality of life, compliance to treatment in patients undergoing renal replacement therapy. It was found that in patients undergoing dialysis therapy without accompanying diabetes, there is a direct correlation between blood pressure and the level of anxiety and depression in patients without and with diabetes. Similar changes are observed in patients undergoing peritoneal dialysis. In patients on programmed and peritoneal dialysis with and without concomitant diabetes there is a pronounced inverse correlation between the value of systolic blood pressure and components of quality of life and compliance. Dialysis patients are exposed to a number of components that significantly increase cardiovascular risk, and the elimination of which can significantly improve the effectiveness of therapy in dialysis patients and reduce the degree of cardiovascular risk. These factors include anxiety and depression, quality of life, and compliance to treatment. They are organically interconnected and significantly affect the leading cardiovascular risk factors and, first of all, arterial hypertension.

Переглянути

Перегляд Світ медицини та біології. 2023 за Дата публікації

Результатів на сторінці

Налаштування сортування