Кафедра дитячої стоматології

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    Establishing the relationship between the level of interleukin-18 and the state of periodontium in children of primary-school-age with chronic catarrhal gingivitis and insulin-dependent diabetes mellitus
    (Полтавський державний медичний університет, 2022) Sheshukova, O. V.; Kuz, I. O.; Maksymenko, A. I.; Trufanova, V. P.; Polishchuk, T. V.; Mosiienko, A. S.; Kazakova, K. S.; Шешукова, Ольга Вікторівна; Кузь, Ірина Олексіївна; Максименко, Аліна Іванівна; Труфанова, Валентина Петрівна; Поліщук, Тетяна Вікторівна; Мосієнко, Анна Сергіївна; Казакова, Катерина Станіславівна
    Insulin-dependent diabetes mellitus is a significant risk factor for inflammatory periodontal disease in children and adolescents. The study aimed to determine the dental status and study the content of pro-inflammatory IL-18 in oral fluid in primary school children with insulin-dependent diabetes mellitus and to develop an algorithm for predicting IL-18 levels in oral fluid of children with chronic catarrhal gingivitis in type I diabetes mellitus background by establishing a relationship between the level of IL-18 and the assessment index of periodontal tissues according to the Sillness scale, Loe. The study examined 82 children aged six to fourteen years, including 56 with type I diabetes and 26 without concomitant somatic diseases. The IL-18 amount in the oral fluid to characterize the inflammation in the oral cavity organs was determined. The IL-18 value increases with the periodontal index and bleeding gums during probing. It is consistent with the data of scientific studies on IL-18 amount in the oral fluid of adults without diabetes. Our study results also show that an increase in the IL-18 value in oral fluid is closely related to type I diabetes in children. Moreover, in our opinion, IL-18 can be considered a potential biomarker of inflammation in periodontal disease in children with type I diabetes mellitus, the clinical manifestations of which are not yet visible. We found that IL-18 levels are elevated even in the absence of clinical gingivitis manifestations. Therefore, establishing IL-18 pathogenetic significance in chronic catarrhal gingivitis on the background of type I diabetes is extremely important.