Кафедра шкірних та венеричних хвороб

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Allelic polymorphisms of dna repair genes and their influence on the formation of resistance to the development of bronchopulmonary pathology under the action of industrial aerosols
(Wydawnictwo Aluna, 2019) Andrushchenko, T. A.; Goncharov, S. V.; Dosenko, V. E.; Ishhejkin, K. E.; Іщейкін, Костянтин Євгенович
In Ukraine, annually, 6-8 thousand occupational diseases are registered, 70% of those are bronchopulmonary pathologies (BPP) [1]. The nature, clinical course and complications of BPP depend on the composition of the industrial aerosols, their aggressiveness and genetic predispositions and immunological characteristics of the individual [2]. In living organisms, there are various systems that protect from exogenous damaging agents, such as DNA repair [3-7]. There are 4 basic DNA repair systems: base-excision repair (BER); nucleotide excision repair (NER); double-strand break repair (DSBR), which is divided into homologous recombination (HR) and non-homologous end joining (NHEJ); mismatch repair (MMR). Most of the damages to DNA (up to 70%) are removed by BER [8]. The genes encoding for BER are characterized by a high level of polymorphism, which, due to changes in the activity of reparative enzymes, can affect individual sensitivity to the actions of various genotoxic agents, including tobacco smoke and industrial aerosols. The XRCC1 gene (X-ray-repair cross-complementing group 1) is localized on the 19-th chromosome (19q13.2). A protein that it encodes, regulates the regeneration of DNA molecules that have been damaged by ionizing radiation and alkylating agents [3, 8-9]. The XRCC3 gene (X-ray-repair cross-complementing group 3) is involved in recombinant DNA repair and double-stranded DNA breaks [10]. The protein products of the NER genesare involved in the removal of the damaged nucleotides with the subsequent restoration of the structure of the DNA molecule, through the recognition and correction of basal cross-linking [11]. The XPD protein (xeroderma pigmentosum group D) functions at the beginning of the synthesis of all proteins as a subunit of the complex protein TFIIH, a complementary factor of RNA polymerase II [5, 6]. The main function of the ERCC1 gene (Excision repair cross complementing 1) is nucleotide recovery [11]. Variants of DSBR errors lead to different types of mutations and chromosome rearrangements that induce a genome instability and carcinogenesis [3, 6]. The gene XRCC7 (X-ray-repair cross-complementing group 7) is located on the 8th chromosome (8q11), encodes a protein which is a large catalytic subunit of the DNA-PC complex (DNA-PKc), which forms an active protein kinase with Ku and initiates recovery by NHEJ [8, 13, 14]. The ataxia-telangiectasia mutation (ATM) gene is localized on the 11th chromosome (11q22-23), encoding the DNA-dependent proteincanase, localized mainly in the nucleus. The carriers of mutant alleles are characterized by sensitivity to radiation, multiple defects in development, predisposition to oncology [15]. A special place among the DNA repair systems belongs to the MMR, thanks to which it is possible to preserve genetic information even when there is a high number of mutations. The MLH1 gene (mutL (E. coli) homolog 1) is located on chromosome 3, encoding a protein that regulates the replacement of improperly coupled DNA bases and is inactivated by methylation [16]. Consequently, there is a lot of data on DNA repair of SNPs associated with high risk factors for lung carcinogenesis due to tobacco smoke, therefore we decided to study these molecular markers in people working in an environment in which industrial aerosols have an impact on them.
Analysis of the effect of chlamydia trachomatis on pregnancy
(ISG-KONF.COM, 2023) Vasylyeva, K.; Bezeha, O.; Yemchenko, Ya.; Васильєва, Катерина Володимирівна; Безега, Олена Вікторівна; Ємченко, Яна Олександрівна
1. The widespread prevalence of urogenital chlamydia in pregnant women, its asymptomatic course, and the possibility of intrauterine infection of the fetus indicate the importance of examining pregnant women for chlamydial infection, especially in risk groups (in women with a complicated obstetric or gynecological history). 2. As a result, given the high prevalence of urogenital chlamydia in pregnant women and its significant role in the development of complications in the mother and fetus, timely etiotropic therapy has a beneficial effect on the course of pregnancy and contributes to the birth of healthy children. To reduce the risk of STD infection (chlamydia and other venereal diseases), it is necessary to disseminate information about the harmful effects of these infections on reproductive function, complications of the course
Analysis of the incidence of urogenital chlamydial infection in pregnant women in the poltava region
(International Scientific Unity, 2024-05-29) Bezeha, O.; Vasylyeva, K.; Yemchenko, Ya.; Dudchenko, M.; Безега, Олена Вікторівна; Васильєва, Катерина Володимирівна; Ємченко, Яна Олександрівна; Дудченко, Микола Олексійович
Despite the fact that there has been a significant decrease in the incidence of sexually transmitted diseases in recent years, the number of cases of mixed infections, as well as individual nosologies, including chlamydia, has increased significantly. However, a large number of infections caused by Chlamydia trachomatis remain unknown. According to the World Health Organisation (WHO), almost 100 million new cases of C. trachomatis are reported annually worldwide. In 2009, the US Centers for Disease Control and Prevention (CDC) reported 1244180 cases of chlamydial infection, but the actual number is at least 2 times higher - about 3 million cases, as the majority (70-90%) of episodes of chlamydial infection of the lower urogenital tract in women are asymptomatic and therefore remain undiagnosed.
Application of hyaluronic acid in skin care of women in perimenopausal and menopausal periods
(European Scientific Platform, 2021) Vasylyeva, K.; Yemchenko, Ya.; Bezeha, O.; Kameniev, V.; Dudchenko, M.; Васильєва, Катерина Володимирівна; Ємченко, Яна Олександрівна; Безега, Олена Вікторівна; Каменєв, Володимир Іванович; Дудченко, Микола Олексійович
Population aging is an important socio-demographic process that receives special attention. In the XX century, in the developed countries of the world, the number of people aged 55 and over increased from about 4 to 13%, topto there is a tendency for these indicators to grow [3,6]. It is this demographic situation that determines the increased attention to research in the field of aging, especially in relation to its potential age-related changes [3,6,11]. Skin aging is part of the overall biological aging process and is governed by the same laws. With age, diseases approach, the colors of life fade, physical activity and sexual desire decrease, chronic fatigue increases [3,5,6,8]. The reason for these problems is the extinction of the function of the reproductive system against the background of general aging of the body [7,8,11]. The skin is the first to react to changes in the body, and also takes on the action of exogenous (climatic changes, UV, lifestyle, etc.) and endogenous factors [1,2,5]. An important endogenous factor in skin aging, especially in women, is the state of the endocrine system [4,5,8,9]. The age periods of a woman are characterized by certain changes both in the reproductive system and in the whole body as a whole. This process can begin long before the onset of menopause (about 35- 40 years), which depends on how strong the sexual constitution and the healthy body of the woman as a whole [5,9].
Application of pioglitazone in the comprehensive treatment of psoriatic patients with concomitant alimentary obesity
(Полтавський державний медичний університет, 2020) Yemchenko, Ya. O.; Ishcheikin, K. Ye.; Kaidashev, I. P.; Ємченко, Яна Олександрівна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор Петрович
Psoriasis is one of the most common chronic recurrent systemic autoimmune multifactorial diseases, in which the skin, joints, internal organs and systems of the body are involved in the pathological process. Despite the significant preva-lence of psoriasis and a large number of studies on this problem, there is still no single view on the pathogenesis of this dermatosis. To objectively understand the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidity of this pathology. Recently, an indisputable link between psoriasis and obesity has been proven. The scientific literature widely covers the issue of identical pathogenetic mechanisms of inflammatory processes in psoriasis and obesity. Given the current data on the role of systemic inflammation underlying the development of both psoriasis and obesity, the study of molecular mechanisms of its development and taking into account the role of proinflammatory nuclear transcription factors, thiazolidinediones are the pathogenetically justified drugs of choice for treatment of these diseases. In this study, we determined the effectiveness of using 15 mg of pioglitazone once a day for 6 months in the treatment of patients with extensive psoriasis vulgaris of moderate severity and concomitant grade І-ІІ alimentary obesity by clinical and immunological examination of systemic inflammation. Analyzing the results of the study, it was found that long-term use of pioglitazone, even in small doses, led to a decrease in systemic inflammation and con-tributed to a milder course of psoriasis in recurrence of the disease.
Bioethical problems arising in the study of single-nucleotide gene polymorphisms of occupational diseases
(Wydawnictwo Aluna, 2020) Andrushchenko, T. A.; Goncharov, S. V.; Dosenko, V. E.; Ishhejkin, K. E.; Іщейкін, Костянтин Євгенович
In Ukraine, about 3 million people work in hazardous and dangerous conditions. The study of hereditary specificity in development of occupational diseases is being actively conducted through molecular genetic analysis of single-n udeotide gene polymorphisms. While studying single-nucleotide gene polymorphisms of occupational diseases, many complicated bioethical questions arise regarding the confidentiality of personal data, the choice between the profession chosen and the risk to one's own health. Complicated bioethical issues that arise when studying single-nudeotide gene polymorphisms of occupational diseases need to be actively discussed, not only by physicians, occupational pathologists, employers, scientists, but also by politicians and lawyers, taking into account ethical and social norms and implications.
Circadian rhythm and indicators of systemic inflammation in patients with psoriasis and concomitant alimentary obesity
(Полтавський державний медичний університет, 2021) Yemchenko, Ya. O.; Ishhejkin, K. Ye.; Kaidashev, I. P.; Ємченко, Яна Олександрівна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор Петрович
Psoriasis is one of the most common dermatoses, affecting from 2% to 4% of the world's population, according to the statistics from WHO. The recent increase in the incidence of comorbid psoriasis and obesity leads to severe, atypical, disabling, and treatment-resistant forms of dermatosis, which significantly impair the quality of life of patients, reduce the efficiency and social activity of patients, thus acquiring not only a medical but also a social significance. There is a theoretical justification for a possible role of circadian rhythm disorders, manifested by changes in eating behavior, reduced sleep duration, and individual chronotype of patients in the development of obesity, chronic low-intensity inflammation, and some chronic autoimmune diseases such as psoriasis. However, this issue remains understudied and insufficiently substantiated. Therefore, the aim of our research was to identify the correlation between the circadian rhythm in terms of changes in the chronotype of human working capacity and indicators of systemic inflammation in patients with extensive psoriasis and concomitant alimentary obesity. The results of correlation analysis showed a high negative correlation between the working capacity chronotype in patients and the level of IL-33, as well as a medium negative correlation between the working capacity chronotype in patients and the level of IL-6 and CRP. Therefore, changes in the circadian rhythm to the evening type of human working capacity chronotype may increase the level of systemic inflammation in patients with extensive vulgar psoriasis and concomitant alimentary obesity. Thus, further in-depth study of the relationship between systemic inflammation and circadian rhythm changes in patients with extensive vulgar psoriasis and concomitant alimentary obesity is promising and essential for the development of scientifically substantiated principles for early prevention and timely correction of these comorbidities.
Correlation analysis of circadian rhythm with severity of psoriasis and obesity
(Полтавський державний медичний університет, 2023) Yemchenko, Y. O. ; Kaydashev, I. P.; Ischeykin, K. Ye.; Bezeha, O. V.; Vasylyeva, K. V.; Oliinichenko, Ya. O.; Morokhovets, H. Yu.; Ємченко, Яна Олександрівна; Кайдашев, Ігор Петрович; Іщейкін, Костянтин Євгенович; Безега, Олена Вікторівна; Васильєва, Катерина Володимирівна; Олійніченко, Ярина Олександрівна; Мороховець, Галина Юріївна
The recent increase in cases of comorbidity of psoriasis and obesity leads to severe, atypical, disabling, and therapyresistant forms of dermatosis, significantly worsen the quality of life of patients, reduces work capacity and social activity of patients, which determines not only the medical but also the social significance of the problem. There is a theoretical rationale for the possible role of circadian rhythm disturbances, manifested by a change in eating behavior, a decrease in sleep duration, and the individual chronotype of patients in developing obesity and some autoimmune diseases. However, this issue remains insufficiently studied and proven. The purpose of our study was to identify the correlation between the circadian rhythm and indicators of changes in the chronotype of a person's working capacity and indicators of the severity of the course of psoriatic disease, the degree of obesity, and the degree of the negative impact of the disease on the quality of life of patients. The results of the correlation analysis showed a very high negative correlation between the chronotype of patients' working capacity and BMI indicators and a high negative correlation between the indicators of the PASI index, ACTIVITY, and the chronotype of patients' working capacity.
Dynamics of clinical and laboratory indicators in the treatment of patients with psoriasis and concomitant alimentary obesity
(Полтавський державний медичний університет, 2021) Yemchenko, Ya. A.; Ishhejkin, K. Ye.; Kaidashev, I. P.; Ємченко, Яна Олександрівна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор Петрович
Psoriasis is the most common chronic, genetically determined autoimmune polyetiological inflammatory disease with impaired epidermal proliferation, which is provoked by exogenous and endogenous factors and is manifested by erythematous and scaly elements, papules and plaques. There is still no consensus on the pathogenesis of this dermatosis. To objectively understand the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidity of this pathology. Numerous studies have shown a clear link between psoriasis and obesity. Systemic inflammation is a common link in the pathogenesis of obesity and psoriasis. In this study, we determined the effectiveness of standard treatment for patients with psoriasis and concomitant grade I-II alimentary obesity, by clinical and immunological examination of systemic inflammation. Found that the treatment of patients was ineffective and further led to the deterioration of patient’s condition due to increased systemic inflammation, the progression of obesity and a more severe course of psoriasis.
Efficacy of long-acting penicillins in combination with doxycycline in the treatment of early stage syphilis
(ISG-KONF.COM, 2023) Bezeha, O.; Vasylyeva, K.; Yemchenko, Ya.; Безега, Олена Вікторівна; Васильєва, Катерина Володимирівна; Ємченко, Яна Олександрівна
During a comparative analysis of the dynamics of KSR negation in the main group of patients who received benzytinbenzylpenicillin in combination with doxycycline, and the comparison group who received the sodium salt of benzylpenicillin, no significant differences were found (Figs. 1-3). This testifies to the approximately equal effectiveness of both methods during the treatment of early forms of active syphilis. Thus, in patients who were treated with benzathine benzylpenicillin in combination with doxycycline, the negation of the complex of serological reactions to syphilis occurred faster compared to patients who were treated only with benzathine benzylpenicillin. This testifies to the favorable long-term results of the method being studied and its high effectiveness for medicine treatment of early syphilis. The method is easy to use and can be recommended for outpatient treatment.
Experience of treatment for fungal diseases in Poltava region
(International Science Group, 2022-04) Vasylyeva, K.; Bezeha, O.; Yemchenko, Ya.; Васильєва, Катерина Володимирівна; Безега, Олена Вікторівна; Ємченко, Яна Олександрівна
Experimental study of the influence of iron oxide colloidal solutions with nanoparticles on the cardiovascular system of rats
(Полтавський державний медичний університет, 2022) Trachtenberg, I. M.; Ischeikin, K. Ye.; Dmytrukha, N. M.; Andrusyshyna, І. М.; Kozlov, K. P.; Lehkostup, L. A.; Tsapko, V. G.; Іщейкін, Костянтин Євгенович
The purpose of the study was to establish the toxic effect of Fe2O3 nanoparticles of different sizes on the cardiovascular system after long-term exposure. Experimental rats were injected intraperitoneally 5 times a week with colloidal solutions of Fe2O3 (with particles of 19, 75 and 400 nm) in a dose of 1 mmol (0.112 mg/ml of iron) per 100 g of the rat's body weight, a total of 30 injections. To establish the cardiotoxic effect of Fe2O3 colloidal solutions, haematological, biochemical and electrocardiographic parameters were determined and compared with the data in the control group. It was established that the long-term intake of Fe2O3 solutions caused disruptions in the process of hemoglobin synthesis; changes in blood coagulation parameters with signs of hypercoagulation; damage to liver and heart cells and increased activity of AST, ALT, AP, LDG, total CK and CK-MB enzymes. The cardiotoxic effect due to the exposure to Fe2O3 colloidal solutions was manifested by disruptions of the contractile and conduction function of the heart. It was noted that the Fe2O3with 19 nm NPs had a more pronounced effect on the cardiovascular system of rats. Метою дослідження було встановлення токсичної дії наночастинок Fe2O3 різного розміру на серцево-судинну систему за умовиїх тривалого надходженняв організм щурів. Піддослідним щурам уводили в очеревину 5 разів на тиждень колоїдні розчини Fe2O3 (з частинками 19, 75 і 400 нм) удозі 1 мл (0,112 мг/мл заліза) на 100 гмаси тіла щура, всього 30 введень. Для встановлення кардіотоксичної дії колоїдних розчинів Fe2O3 визначали гематологічні, біохімічні та електрокардіографічні показники, які порівнювали з даними в контрольній групі щурів. Встановлено, що тривале надходження розчинів Fe2O3 в організм щурів викликало порушення процесу синтезу гемоглобіну; зміни показників згортання крові з ознакамигіперкоагуляції;ушкодження клітин печінки, серця та збільшення активності ферментів АСТ, АЛТ, ЛФ, ЛДГ, КК загальна і КК-МВ. Кардіотоксичний ефект за впливу колоїдних розчинів e2O3 проявлявся порушенням скорочувальної та провідної функції серця. Відзначено, що більш виразну дію на серцево-судинну системущурів чинив розчин Fe2O3з НЧ19 нм.
Features of the clinical course of psoriasis in patients with obesity
(International Science Group, 2020) Yemchenko, Ya.; Vasylieva, K.; Bezeha, O.; Ємченко, Яна Олександрівна; Васильєва, Катерина Володимирівна; Безега, Олена Вікторівна
Psoriasis is one of the most common chronic recurrent multifactorial diseases of the skin with a predominance of genetic bias, characterized by hyperproliferation of epidermal cells, impaired keratinization due to inflammatory reaction in the dermis, as well as the lesions of nails and joints [1]. According to the results of clinical and epidemiological studies, about 3-4% of the population of our planet, regardless of gender, age and ethnic group, suffers from psoriasis, and the share of this pathology in the general structure of skin diseases, according to various authors, ranges from 1% to 40 % [2]. However, despite the considerable spread of psoriasis and a large amount of research on this problem, there is still no single view of the pathogenesis of this dermatosis. In order to objectively understand the pathogenesis of psoriasis, it is necessary to take into account the understudied comorbidity of this disease [3].
Features of the clinical course of psoriasis in patients with obesity
(Українська медична стоматологічна академія, 2020) Yemchenko, Ya. O. ; Ischeikin, K. Ye.; Ємченко, Яна Олександрівна; Іщейкін, Костянтин Євгенович
Psoriasis is the most common chronic, genetically determined autoimmune polyetiological inflammatory disease with im-paired epidermal proliferation, provoked by exogenous and endogenous factors, and manifested by erythematous and scaly elements, papules and plaques. According to the results of clinical and epidemiological studies, psoriasis affects about 3-4% of the population of our planet, regardless of gender, age, and ethnic group, and the specific gravity of this pathology in the general structure of skin diseases reaches, from the data of different authors, from 1% to 40 %. How-ever, despite the significant incidence of psoriasis and a large amount of research on this problem, there is still no single view of the pathogenesis of this dermatosis. For an objective understanding of the pathogenesis of psoriasis, it is neces-sary to take into account the insufficiently studied comorbidity of this pathology. Therefore, in the studies of the patho-genesis of psoriasis in recent years, more attention is paid to the impairment of metabolic processes. Recently, an indis-putable link between psoriasis and obesity has been proven. Obesity has been found to increase the risk of many dis-eases, including psoriasis. The literature has broadly highlighted the question of the pathogenetic mechanisms of in-flammatory processes in psoriasis and obesity that form a vicious circle at the level of the immune system, which must be broken for the successful treatment of these diseases. In this research, we studied the clinical presentation of the disease, measured anthropometric parameters, determined the grade of obesity by BMI, analyzed the history of life and disease, and conducted clinical and biochemical blood tests. The results of the study revealed that alimentary obesity in patients with psoriasis leads to metabolic disorders, complicating the course of dermatosis, which leads to a worsening of the DLQI of patients, the inefficiency of standard methods of therapy and frequent exacerbations of psoriatic disease. Therefore, the prospect for further research is a more in-depth study of the comorbidity of psoriatic disease, which will identify new targets for the treatment of this dermatosis to prevent complications and more effective treatment of this pathology.
Features of the clinical course of psoriasis patients with grade I-II alimentary obesity
(International Science Group, 2020) Yemchenko, Ya.; Vasylieva, K.; Bezeha, O.; Ємченко, Яна Олександрівна; Васильєва, Катерина Володимирівна; Безега, Олена Вікторівна
Psoriasis is one of the most common chronic recurrent multifactorial diseases of the skin with a predominance of genetic bias, characterized by hyperproliferation of epidermal cells, impaired keratinization due to inflammatory reaction in the dermis, as well as the lesions of nails and joints. According to the results of clinical and epidemiological studies, about 3-4% of the population of our planet, regardless of gender, age and ethnic group, suffers from psoriasis [2,15]. However, despite the considerable spread of psoriasis and a large amount of research on this problem, there is still no single view of the pathogenesis of this dermatosis. In order to objectively understand the pathogenesis of psoriasis, it is necessary to take into account the understudied comorbidity of this disease.
Formation of stress resistance and changes in cognitive functions under the influence of a complex of chemical food additives
(Azərbaycan Tibb Universiteti, 2024) Bilash, S. M.; Oliinichenko, Ya. O.; Pronina, O. M.; Donchenko, S. V.; Koptev, M. M.; Pirog-Zakaznikova, A. V.; Onipko, V. V.; Oliinichenko, M. O.; Bezeha, O. V.; Mamai, O.V.; Білаш, Сергій Михайлович; Олійніченко, Ярина Олександрівна; Проніна, Олена Миколаївна; Донченко, Світлана Владиславівна; Коптев, Михайло Миколайович; Пирог-Заказникова, Ангеліна Валеріївна; Онипко, Валентина Володимирівна; Олійніченко, Марина Олександрівна; Безега, Олена Вікторівна; Мамай, Олександр Володимирович
The article provides information about a study conducted to investigate behavioral reactions and stress tolerance in rats that were administered chemical food additives (monosodium glutamate, sodium nitrite, Ponso-4R) for different durations. In the study, experimental subgroups of laboratory rats were administered complex chemical food additives daily once orally for 1, 4, 8, 12, 16 and 20 weeks. Cognitive functions were assessed using the “Extrapolation Escape” test. The analysis of the obtained results showed that the estimated indicators at the initial stages of the experiment (up to 8 weeks) had positive dynamics, which was characterised by a reduction in the time of occurrence of reactions. After 12 weeks of introducing the complex of food additives, negative changes occurred, which were manifested by a gradual postponement of the studied indicators. The worst indicators were recorded after week 20 (significant at p<0.05. It was found that the use of a complex of chemical food additives leads to blunted reactions under conditions of acute stress, as well as impaired ability to find a way out of the acute stress situation.
Genetic predisposition to bronchopulmonary pathology
(Українська медична стоматологічна академія, 2020) Andrushchenko, T. A.; Stroy, D. O.; Goncharov, S. V.; Dosenko, V. E.; Ishhejkin, K. E.; Андрущенко, Т. О.; Строй, Д. А.; Гончаров, С. В.; Досенко, В. Є.; Іщейкін, Костянтин Євгенович
We studied 215 people who work in harmful industries, 90 of which had a history of bronchopulmonary pathology of occupational etiology and 125 of them without such pathology. The following polymorphisms of DNA repair genes were identified in real-time using polymerase chain reaction: XPD (rs13181, rs799793), ERCC1 (rs11615), XRCC3 (rs861539), XRCC1 (rs25487), ATM (rs664677), XRCC7 (rs7003908) and MLH1 (rs1799977). We studied the frequency distribution of the genotypes of DNA repair genes with the subsequent integral statistical analysis of the data obtained. Analysis of the results made it possible to build a mathematic model that included two single nucleotide polymorphisms: XRCC1 (rs25487) and ATM (rs664677), which in this study represented the two main independent effects with the greatest predictive power 80.35 % for the results of binary logistic regression and of the method of multivariate dimension reduction.
Il-33 as a biomarker of inflammatory activity in psoriasis patients with concomitant obesity
(Полтавський державний медичний університет, 2021) Yemchenko, Ya. O.; Ischeikin, K. Ye.; Kaidashev, I. P.; Izmailova, O. V.; Ємченко, Яна Олександрівна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор Петрович; Ізмайлова, Ольга Віталіївна
Recently, there has been an increase in cases of comorbid psoriasis and obesity, which leads to severe, atypical, disabling, and therapy - resistant forms of dermatosis which form a vicious circle at the level of the immune system, which must be broken in order to treat these diseases successfully. In this study, we examined the serum IL-33 level and its association with rates of systemic inflammation, the severity of psoriasis and obesity. We applied the enzyme immunoassay to evaluate the severity of systemic inflammation. We determined the concentration of IL-33, interleukin-6, and high sensitivity C-reactive protein in the serum. PASI was used to assess the severity of psoriasis. We used BMI to determine the extent of alimentary obesity. There was a positive statistically significant correlation between the serum IL-33 concentration, the severity of psoriasis, the level of systemic inflammation, and the degree of alimentary obesity
Immune-related mechanisms, molecular and genetic characteristics of patients with the systemic connective tissue diseases with cryoglobulinemic syndrome
(Львівський національний медичний університет імені Данила Галицького, 2021) Lischuk-Yakumovych, K.; Hauduchok, I.; Ishheikin, K.; Chopyak, V.; Ліщук-Якумович, Х.; Гайдучок, І.; Іщейкін, Костянтин Євгенович; Чоп'як, В.
Introduction. Cryoglobulinemic syndrome (CGS) is an immune-related process caused by cryoglobulins composition in the blood in small or medium vessels. Most frequently, CGS is triggered by lymphotropic viruses, immune-related and oncological diseases.Objectives. Studying the immune-related mechanisms, molecular and genetic characteristics of patients with systemic autoimmune diseases (SAD) against the cryoglobulinemic syndrome.Methods. Among 380 patients with SAD, in 94 (57.6%) progressing chronic EBV-infection was diagnosed, and 22.1% of patients were diagnosed with progressing chronic HSV 1/2-infection based on DNA virus identifi cation through the polymerase chain reaction (PCR) in three biological media (blood, saliva, mucus membrane scraping). Results. Analysis of the cryoglobulins in such patients showed that CGS was diagnosed in 118 (31.1%) patients with the mean concentration of CG1.68±0.33 g/l at a rate of 0.48 ±0.10g/l. The patients with the systemic connective tissue diseases with CGS demonstrated statistically lower miR-146а expression which resulted in the abnormal production of pro-infl ammatory cytokines, the highest TLR9 expression on monocytes, slightly lower on lymphocytes, and the lowest on granulocytes; the increase in the relative amount of cytolytic T-lymphocytes, IL2 receptor lymphocytes, activated CD HLA DR+-lymphocytes against the reduction of NK-cells and regulatory suppressor CD4+/25+-cells was observed.The idiopathic and initiated oxidative monocyte capacity in CGS patients distinctly tended to increase, as compared to patients without CGS and normal individuals. Conclusions. Cryoglobulins may act as the so-called bridge between viral infections and the autoimmune processes. CGS was diagnosed in 31.1% of patients. Despite a substantial number of studies dedicated to the cryoglobulinemic syndrome, the peculiarities of the immune reaction of such patients need further research, since they create the risks of secondary vasculitis against SAD.
Lipid parameters before and after immunobiological therapy of patients with psoriasis
(Полтавський державний медичний університет, 2022) Stepanenko, R. L.; Dudchenko, M. O.; Stepanenko, V. I.; Vasylyeva, K. V.; Kameniev, V. I.; Svirid, S. G.; Litinska, T. O.; Степаненко, Р. Л.; Дудченко, Микола Олексійович; Степаненко, В. І.; Васильєва, Катерина Володимирівна; Каменєв, Володимир Іванович; Свирид, С. Г.; Літинська, Т. О.
Psoriasis is one of the most common dermatoses and occupies one of the leading places among the current problems of modern dermatology. 148 patients were involved in the study. Comparative evaluation of the therapeutic efficacy of monotherapy with the immunobiological drug Adalimumab, as well as its combination with a domestic non-hormonal drug based on natural ingredients (Flaxseed oil, Solidol fatty, D-panthenol, Allantoin, Herd extract, Celandine acid extract, Celandine extract) in the examined patients with psoriasis vulgaris was performed according to the dynamics of regression of cutaneous clinical manifestations of dermatosis: reduction of lesion area, regression of erythema, infiltration, peeling of psoriatic skin rash, changes in PASI, PGA, BSA index. We have proposed a modified treatment regimen for patients with psoriasis vulgaris, which provides a course of systemic immunobiological therapy with adalimumab with concomitant use of domestic non-hormonal drug can increase the effectiveness of treatment and prolong the remission of dermatosis. Псоріаз є одним з найбільш поширених дерматозів і посідає одне з провідних місць серед актуальних проблем сучасної дерматології. У дослідженя було залучено 148 пацієнтів. Порівняльна оцінка терапевтичної ефективності застосування монотерапії препаратом імунобіологічної дії Адалімумаб, а також його комбінації з відчизняним негормональним препаратом на основі натуральних компонентів (Лляна олія, солідол жировий, D-пантенол, алантоноїд, екстракт череди, екстракт чистотілу, екстракт оману, сірка, саліцілова кислота) у обстежених хворих на псоріаз вульгарний проводилась згідно динаміки регресу шкірних клінічних проявів дерматозу: зменшення площі ураження, регрес еритеми, інфільтрації, лущення елементів шкірної псоріатичної висипки, змін індексу PASI, PGA, BSA. Запропонована нами модифікована схема терапії хворих на псоріаз вульгарний, яка передбачає проведення курсу системної імунобіологічної терапії препаратом адалімумаб з паралельним призначенням відчизняним негормональним препарату дозволяє підвищити ефективність лікування та подовжити термін тривалості ремісії дерматозу.

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