Наукові праці. Кафедра фармакології

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Androgen imbalance in gouty arthritis in men with obesity
(Wydawnictvo POLIHYMNIA Sp. z o.o., Lublin, 2016) Kapustianska, A.; Zhdan, V.; Bobyriov, V. M.; Chelishvili, A.; Shepitko, V.; Капустянська, Анна Анатоліївна; Ждан, Вячеслав Миколайович; Бобирьов, Віктор Миколайович; Челішвілі, Анатолій Леонідович; Шепітько, Володимир Іванович; Капустянская, Анна Анатольевна; Ждан, Вячеслав Николаевич; Бобырев, Виктор Николаевич; Челишвили, Анатолий Леонидович; Шепитько, Владимир Иванович
Mostly men suffer from gouty arthritis (95% of cases). The most frequent comorbid condition is obesity in men who suffer from gouty arthritis. In men for gouty arthritis obesity found an increase in the level of erythrocyte sedimentation rate (35,5 ± 1,2) and C-reactive protein (13,0 ± 1,2). Found that when gouty arthritis in patients with obesity inflammatory process is not limited to local changes in the joints, but also causes a reaction of the whole organism. There was a decrease the testosterone levels in obese men. It confirms the importance of determining the level of testosterone for gouty arthritis patients with obesity. Thus, the decrease in testosterone levels, especially in the presence of obesity II and III, characterized by maximum hyperuricemia, confirming evidence for an association of abdominal obesity with levels of testosterone in patients with gouty arthritis. A course of gouty arthritis, a form of arthritis and the presence of peripheral tophi affects on hyperuricemia. In turn, the levels of testosterone and uricemia affect the severity of obesity in patients with gouty arthritis. The severity of obesity depends on the indicators of testosterone. We established pathogenetic role of testosterone in the development and progression of gouty arthritis and obesity in men. It is proved that the aggravation of gouty arthritis is accompanied by changes in testosterone levels, depending on the degree of obesity. We find a strong link between the concentration of testosterone and uric acid, as well as stage of disease. It is shown that obesity contributes to the development of degenerative changes in osteo-articular apparatus in violation of motor function. In turn, promotes the development of gouty arthritis, overweight and obesity.
Anhedonia as behavioral marker of experimental neurosis and its correction
(Czech Republic, 2018) Sydorenko, A. H.; Lutsenko, R. V.; Сидоренко, Антоніна Григорівна; Луценко, Руслан Володимирович
Anhedonia correction at different types of chronic stress
(Росія, Санкт-Петербург, 2018) Lutsenko, R. V.; Sydorenko, A. H.; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна; Луценко, Руслан Владимирович; Сидоренко, Антонина Григорьевна
Экспериментальный невроз и хронический умеренный стресс вызывают развитие ангедонии. Лечебно-профилактическое применение производных 2-оксииндолин-3-глиоксиловой кислоты эффективно корректировало ангедонию при экспериментальной патологии.
Antidepressive activity of 2-oksoindolin-3-glycolic acid derivatives in Numero’s test
(Харків, Національний фармацевтичний університет, 2012) Sydorenko, A. G.; Lutsenko, R. V.; Сидоренко, Антоніна Григорівна; Луценко, Руслан Володимирович
Antimicrobial properties of the new combined dental gel
(2023) Devіatkina, Nataliia; Дев'яткіна, Наталія Миколаївна
Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. RotrinDenta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. RotrinDenta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov’ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.
Behavior features of rats in the “Open field” test under the influence of kisspeptin-10
(Taylor & Francis, 2025-05) Hryshko, Yu. M.; Lutsenko, R. V.; Гришко, Юлія Михайлівна; Луценко, Руслан Володимирович
To investigate the specifics of the effect of kisspeptin-10 on the behavioural responses of males and females in the open field test. The experiments were performed on 30 male and 30 female sexually mature white rats weighing 250–270 g. The behavior was studied 1 hour and 24 hours after the introduction of kisspeptin-10, which was administered intranasally at a dose of 0.1 mg/kg (20 μg in 20 μl, 10 μl in each nasal passage). The control group of rats was injected with saline solution intranasally 20 μl, 10 μl in each nasal passage according to a similar scheme. In male rats under the influence of kisspeptin-10, changes in behavioural reactions in the ‘open field’ test were observed, which may indicate a decrease in the animals’ emotionality and anxiety in new living conditions. The established changes in indicators may indicate an improvement in the processes of adaptation to new conditions under the influence of kisspeptin-10, a reduction in anxiety. At the same time, the changes in the animals’ behavior that occurred 24 hours after the introduction of kisspeptin-10 indicate that the rats adapted to the ‘novelty factor’ and decreased interest in being in the ‘open field’ test. Such changes may indicate the presence of a potential positive neurotropic effect of kisspeptin-10. When comparing the behavioral reactions of female and male rats in the ‘open field’ test, we can talk about a more active effect of kisspeptin-10 on the body of males, which was manifested in a decrease in the level of anxiety. Such features of the action of kisspeptin-10 May be due to differences between the sexes in the response to ‘novelty’ in the ‘open field’ test, in particular, males showed more stable behavior and smaller limits of its fluctuation. 1. In the ‘open field’ test, basic intersex differences in the emotionality of rats were revealed. 2. Application of kisspeptin-10 intranasally, in a dose of 20 μg, modified the emotional and behavioral reactions of mainly male rats.
Blood gases and electrolytes under use of magnetite nanoparticles in blood loss
(Полтавський державний медичний університет, 2021) Vazhnichaya, E. M.; Lutsenko, R. V.; Semaka, O. V.; Deviatkina, T. O.; Deviatkina, N. M.; Kurapov, Yu. A.; Litvin, S. Ye.; Важнича, Олена Митрофанівна; Луценко, Руслан Володимирович; Семака, Олександр Валентинович; Дев'яткіна, Тетяна Олексіївна; Дев'яткіна, Наталія Миколаївна; Курапов, Юрій Анатолійович; Литвин, Станіслав Єгорович
Blood gases, acid-base balance, and electrolytes were studied under the conditions of correction of acute blood loss in abino rats with magnetite nanoparticles (5–8 nm) obtained by electron-beam technology and incorporated into sodium chloride crystals. It was shown that blood loss decreases total hemoglobin and the volumetric concentration of oxygen, diminishes sodium concentration and increases potassium concentration in the blood. Dissolved and injected intraperitoneally after the blood loss, magnetite nanoparticles (1.35–6.75 mg iron/kg) reduce the partial pressure of carbon dioxide, increase the partial pressure of oxygen, saturation of hemoglobin with oxygen and volumetric oxygen concentration, increase hydrogen index and sodium content, and reduce potassium concentration in the blood. These positive changes develop against the background of an increase in total hemoglobin. They surpass some effects of the traditional iron preparation and can be the basis for further research aimed at the use of magnetite nanoparticles in acute posthemorrhagic syndrome.
Changes in pharmacological training of future doctors in Ukraine in the context of modernization of medical higher education institutions
(Сумський державний педагогічний університет імені А.С. Макаренка, 2024) Lutsenko, Olga; Луценко, Ольга Анатоліївна
World integration processes and globalization trends have set the tasks of modernization and involvement in the European and world educational space for higher medical education in Ukraine. The periods of changes in the total number of hours and the emergence of independent work in the curricula of pharmacological training of future doctors, which corresponded to Ukraine's accession to the Bologna Process and subsequently to the European Education Area (EEA), are highlighted. The curricula for the study of pharmacology over the past 55 years have been analyzed. The problems that arose in the context of changes in the curriculum, which led to a redistribution of the number of hours in the study of disciplines, are revealed. The directions of resolving the discrepancies between the amount of material and the features of the curricula are characterized. Мета статті. Порівняти та проаналізувати навчальні програми з фармакології для студентів медичних факультетів ЗВО України та на основі проведеного порівняльного аналізу визначити найоптимальніші напрямки модернізації сучасної освітньої діяльності вітчизняних медичних ЗВО згідно з сучасними трендами європейського освітнього простору. Методи дослідження. Використовувалися бібліосемантичний підхід і аналіз наукової літератури, в якій розглядалися окремі аспекти модернізації медичної освіти в незалежній Україні. Також проаналізовані архівні дані, навчальні програми доступні на сайтах медичних університетів України та робочі програми з фармакологія. Результати дослідження. З перших років незалежності вектор української освітньої політики спрямований у бік Європейської інтеграції, зокрема світового і Європейського освітнього простору, що призвело до модернізації стандарту вищої медичної освіти та робочих програм і навчальних планів, зокрема це стосується й фармакологічної підготовки майбутніх лікарів. Практичне значення дослідження. В умовах зростання кількості матеріалу для вивчення та зменшення годин для аудиторної підготовки потрібно запроваджувати ефективні методи навчання, постійно підвищували педагогічну майстерність та активізувати самостійну роботу студентів через освітню платформу E‐Aristo. Ці матеріали містять презентації, аудіо та відеоматеріали та включають матеріали для навчання та контролю знань. Висновки. Викладачі з фармакології повинен мати глибокі теоретичні знання, розуміння предмета та мати практичний і педагогічний досвід, який повинен поєднуватись з ґрунтовними педагогічними знаннями та навичками. Це вочевидь зробить фармакологічну підготовку майбутніх лікарів цікавою та захоплюючою, за рахунок запровадження новітніх методів навчання. Перспективи подальших наукових розвідок. У подальшому планується розглянути удосконалення методичних підходів, що забезпечать покращення самостійної роботи здобувачів освіти.
Chronic obstructive pulmonary disease and comorbidities: management of somatoform disorders
(Aluna Publishing, Польща, 2021) Burya, L. V.; Kapustianska, A. A.; Moiseieva, N. V.; Vakhnenko, A. V.; Rumiantseva, M. O.; Zviagolska, I. M.; Буря, Лілія Володимирівна; Капустянська, Анна Анатоліївна; Моісєєва, Наталія Віталіївна; Вахненко, Андрій Вікторович; Рум'янцева, Марія Олександрівна; Звягольська, Ірина Миколаївна
The aim: To perform a comprehensive evaluation of the effect of paroxetine on the degree of somatoform disorders in exacerbation of severe COPD in women. Materials and methods: The study involved 53 female patients with severe COPD (Group D), confirmed by instrumental methods of study. At hospitalization, patients were divided into 2 groups. Patients of Group 1 (n = 21; aged 52.5 ± 0.8 years old) underwent basic exacerbation therapy. Patients of Group 2 (n = 22; aged 57.9 ± 0.4 years old) underwent basic exacerbation therapy supplemented with paroxetine for 14 days, 1 tablet (0.20 g) once a day. Results: The basic therapy for treatment of COPD exacerbations, supplemented with paroxetine, led to a positive clinical effect, confirmed by increase in skeletal and respiratory muscular system, increased parameters of pulmonary ventilation, increased tolerance to physical load, increased oxygen saturation, decreased heart rate and breathing rate. Conclusions: The strategy for choosing an antidepressant to provide multidisciplinary care for somatoform disorders in women with exacerbation of severe COPD (group D) should take into account the efficacy and favorable safety profile and personalization of the drug. In exacerbation of severe COPD, the degree of somatoform disorders in patients correlates with the severity of the main criteria: FVC1, the distance walked during the 6-minute step test, oxygen saturation after the 6-minute step test, end-expiratory pressure in the oral cavity.
Circadian rhythms: physiological and pathophysiological aspects
(Springer Nature, 2022) Drogovoz, S. M.; Seredyns’ka, N. M.; Shtroblya, A. L.; Luk’yanchyuk, V. D.; Lutsenko, R. V.; Krutskykh, T. V.; Panfilova, A. L.; Derymedvid’, L. V.; Shtroblya, M. V.; Луценко, Руслан Володимирович
Physiological and pathophysiological aspects of the functioning of the cerebral system (hypothalamus and cerebral epiphysis) providing the circadian rhythm in humans are described with special attention to the involvement of disorders in this system in the pathogenesis of some neurodegenerative diseases and epilepsy.
Clinical, pharmacotherapeutic and biorhythmological peculiarities of depressive disorders, comorbid with cardiovascular pathology
(м. Тбілісі, 2021) Hryn, K.; Sydorenko, A.; Vlasova, O.; Kolot, E.; Martynenko, Y.; Гринь, Катерина Вікторівна; Сидоренко, Антоніна Григорівна; Власова, Олена Вікторівна; Колот, Еліна Георгіївна; Мартиненко, Яніна Павлівна
The spread of depressive disorders is extra high nowadays. Depressive disorders are widespread mental disorders in the structure of mental pathology, both causes of psychiatrists’ visit, and causes of medical aid. The presence of depressive syndrome in patients with cardiovascular system leads to deterioration patient’s condition and adaptive abilities and aggravates somatic abnormality. Adequate therapy causes their reduction, prevention of recurrence and decompansation of comorbid somatic pathology, and eliminates severe medical and prevents social consequences. The study of clinical aspects of depressive conditions which are accompanied with pathology is one of the direction not only psychiatric, but also common pharmacotherapeutic investigations. The aim of the investigation was to determine clinical, pharmacotherapeutic and biorhythmic peculiarities of depressive disorders in patients with comorbid cardiac pathology. And also assessment of efficacy of complex therapy based on chronotherapy principle was used. 50 patients (female patients) with depressive disorders were involved in this investigation. This was performed based on “Depressive disorders of organic genesis, characterized by somatic pathology” (F 06.35), “Somatoform disorder” of heart and cardiovascular system (F 45.30), “Mild depressive episode” (F 32.00), and also comorbid arterial hypertension confirmed by physician. Clinical, laboratory, clinical and psychopathological investigations using psychodiagnostic scales (scale HAMD-21, CGI-S, CGI-І) were used. Individual biorhythmic status was established and it requires medicamentous therapy. Comparing patients of both groups, it has been detected a group of patients in whom principles of chronotherapy, especially antihypertensive and antidepressive therapy were prescribed, dynamics of patient’s improvement was better than in the investigated group where the principle of chronotherapy was observed.
Combined pharmacological therapy including several antiarrhythmic agents for treatment of different disorders of cardiac rhythm
(Грузія, м. Тбілісі, 2021-06) Kapustnick, Yu. ; Lutsenko, R.; Sуdorenko, A.; Капустник, Юрій Олексійович; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна; Капустник, Юрий Алексеевич; Луценко, Руслан Владимирович; Сидоренко, Антонина Григорьевна
Combined therapy using several antiarrhythmic agents can be useful for treatment of different disorders of cardiac rhythm, including their hazardous and stable forms. It is especially re-quired in case of insufficient efficacy after using one antiarrhythmic agent. As a combined therapy one can use the administra-tion of several preparations e.g. 1) preparations of IA subclass and β-blocker adrenergic agents; 2) antiarrhythmic agents of I class and calcium channel blocker agents (verapamil and dil-thiazem); 3) III class (amiodarone or sotalol) together with β-blocker drugs; 4) antiarrhythmic agents of III class and calcium antagonists; 5) antiarrhythmic agents of I and III classes. The latter combination has especially strong effect for treatment of arrhythmias caused by re-entry mechanism with or without a short excitability period. Antiarrhythmic agents of II class (β-blocker drugs) and III classes (amiodarone or sotalol) cause reduction of development risk of arrhythmias with trigger mechanism, including bidirectional spindle-shaped ventricular (torsade de pointes) tachycardia. Thus, combinations including preparations of II class together with III class and simultaneous using of antiarrhythmic agents of I and III classes should be administered to prevent hazardous potentially lethal arrhythmias. The authors of this article have developed a new method of combined therapy of paroxysmal supraventricular tachyarrhythmias in patients with ischemic heart disease, including the use of allapinin and cardiac glycosides. The author’s certificate of invention was obtained for this method. The efficacy of this combined therapy for suppression of supraventricular paroxysmal tachyarrhythmias was analyzed compared to treatment with allapinin alone. It was proved that combined therapy has bigger effectiveness in comparison with therapy with help allapinin only. It is forbidden to use of such combinations of antiarrhythmic agents: β-adrenergic blocker agent + verapamil; β-adrenergic blocker agent + dilthizem; propafenone + verapamil; propafenone + dilthizem; propafenone + β-adrenergic blocker agent. After administration of such combined therapy, it is possible the occurrence medicinal (toxic) disfunction of sinus node. The administration of propafenone together with β-adrenergic blocker agent is impossible because propafenone has properties of β-blocker preparation. It is connected with similar chemical structure of propafenone and non-selective β-blocker agent propranolol.
Comprehensive patterns of comorbidity: copd and depression
(Wydawnictwo Aluna, 2018) Moisieieva, N. V.; Burya, L. V.; Kapustianska, A.; Kolenko, I. O.; Rumyantseva, M. A.; Shumeiko, O. H.; Моісєєва, Наталія Віталіївна; Буря, Лілія Володимирівна; Капустянська, Анна Анатоліївна; Коленко, Ірина Олексіївна; Рум'янцева, Марія Олександрівна; Шумейко, Олексій Григорович
Introduction: Data on the prevalence of psychopathological disorders in the exacerbation of chronic obstructive pulmonary disease (COPD) are very heterogeneous. COPD and depression have common predisposing factors. The aim: The aim of the research is to conduct a comprehensive assessment of the e»ect of paroxetine on the level of depressive disorders in the exacerbation of severe degree COPD in women. Materials and methods: The study included patients with severe degree COPD and depressive disorder. A step-by-step test, dynamometry of muscular strength of muscle groups and calculation of the percent ratio of muscular strength to mass were performed for all patients, and the strength of the respiratory muscles was measured. To assess the level of depression, the HADS questionnaire and the CES-D self-questionnaire were used. Assessment of the severity of the patient’s condition was conducted according to the Hospital Alert and Depression Scale (HADS). Results: In exacerbation of severe COPD, the level of depression in patients correlates with the severity of the main criteria: FEV1, the 6-minute step test distance, oxygen saturation after the 6-minute step test, expiratory pressure in the oral cavity. Conclusions: Upon the synchronization of the standard therapy, the level of depression in patients with exacerbation of severe COPD e»ectively decreases. Paroxetine is a valid choice in the comprehensive treatment of COPD. According to the data of evidence-based medicine, the medication demonstrates high eÈciency and favorable safety pro le, without exerting a negative e»ect on COPD, which is of key signi cance in the combined pathology treatment.
Correction of movement stereotype in patients with spastic forms of cerebral palsy
(Polish Academy of Sciences, 2014) Strashko, Ye. Yu.; Bobyrova, L. E.; Kapustianska, A. A.; Yushkovska, O. G.; Fedorovych, L. O.; Страшко, Євген Юрійович; Бобирьова, Людмила Єгорівна; Капустянська, Анна Анатоліївна; Юшковська, Ольга Геннадіївна; Федорович, Людмила Олександрівна; Страшко, Евгений Юрьевич; Бобырева, Людмила Егоровна; Капустянская, Анна Анатольевна
In this article, the author proposed a rehabilitation program, which includes the impact on the body of patients with cerebral palsy throughout the bio muscle kinematic chain, taking into account the construction of the spiral body muscles during rehabilitation procedures.
Current strategy for treatment of comorbid states: complicated community-acquired pneumonia with arterial hypertension
(Wydawnictwo Aluna, Polska, 2020) Burya, L. V.; Vakhnenko, A. V.; Moiseieva, N. V.; Kapustianska, A. A.; Zviagolska, I. M.; Буря, Лілія Володимирівна; Вахненко, Андрій Вікторович; Моісєєва, Наталія Віталіївна; Капустянська, Анна Анатоліївна; Звягольська, Ірина Миколаївна; Буря, Лилия Владимировна; Вахненко, Андрей Викторович; Моисеева, Наталья Витальевна; Капустянская, Анна Анатольевна; Звягольская, Ирина Николаевна
The aim: To optimize the treatment of CAP patients with hypertension, complicated by exudative pleuritis. Materials and methods: The study included 43 CAP patients, aged 46 to 65 years, with viral lesions along with hypertension. The average age of the patients was 52.5 ± 4.5 years. Veri cation of the CAP diagnosis and its formulation was performed in accordance with the order of the Ministry of Health of Ukraine No. 128 of 19.03.2007 “On the approval of clinical protocols of medical care in “Pulmonology” in all patients, pneumonia was complicated by exudative pleuritis, which was con rmed by X-ray examination. Results: The use of combination drugs, namely, torasemide with prolonged e ect and tivortin aspartate in the treatment of patients with community-acquired pneumonia, complicated by exudative pleuritis, combined with hypertension led to more signi cant positive changes in the values of saturation, blood biochemical parameters, as well as accelerated recovery of patients, which was con rmed by the positive dynamics of X-ray examination. Conclusions: As a result of the treatment, all parameters of the quality of life of the patients were greatly improved, which resulted in a signi cant reduction in functional limitations and high social activity of the patients, which signi cantly reduced the cost of treatment.
Cytotoxicity of magnetite nanoparticles deposited in sodium chloride matrix and their functionalized analogues in erythrocytes
(ELSEVIER, 2023) Lytvyn, Stanislav; Vazhnichaya, Elena; Kurapov, Yurii; Semaka, Oleksandr; Babijchuk, Lyubov; Zubov, Pavlo; Важнича, Олена Митрофанівна
The synthesis of covered nanoparticles provides new properties to the materials for biomedical applications. This fully applies to iron oxide nanoparticles. The research aim was to study features of the magnetite nanoparticles synthesized by electron beam technology as well as to investigate their functionalization and cytotoxicity. Nanoparticle characteristics were determined by stan dard methods. Cytotoxiciy of nanoparticles was studied using erythrocyte model. It was shown that the original magnetite nanoparticles in the sodium chloride matrix can be functionalized with polyvinylpyrrolidone and ethylmethylhydroxypyridine succinate, an antioxidant. All investigated nanoparticles were non-toxic for erythrocytes at concentrations up to 100 μg Fe/ml. At 100-200 μg Fe/ml, they increased the amount of cells expressing phosphatidylserine on the outer membrane, the count of pathological forms of erythrocytes and hemolysis. These phe nomena were less pronounced if the nanosystem included the antioxidant. Therefore, magnetite nanoparticles can be obtained by electron beam technology and functionalized to form non-toxic nanosystems.
Disorders of cardiac rhythm in patient with syndrome preexitation of ventricles and their pharmacological correction
(Українська медична стоматологічна академія, 2020) Lutsenko, R. V.; Kapustnick, Yu. A.; Sydorenko, A. H.; Луценко, Руслан Володимирович; Капустник, Юрій Олексійович; Сидоренко, Антоніна Григорівна
The goal of investigation was analysis of possibility of using of different antiarrhythmic agents in patients with syndrome preexitation and disorders of cardiac rhythm. Most typical disorders of cardiac rhythm in patient with syndrome preexitation are ortodromic reciprocating supraventricular tachycardia, antidromic supraventricular tachycardia, atrial fibrillation and atrial fibrillation. During attack of tachycardia in patients with syndrome of preexitation can be different clinical symptoms. They can range from mild palpitation to syncope. This tachycardia can be even reason of sudden cardiac death. Main its mechanism is macroreentrant circuit involving the AV-node, the additional pathway, the atrias, the ventricles. Attacks of atrioventricular reciprocating tachycardia in patients with WPW syndrome and with narrow complexes QRS calcium channel blocker verapamil has efficacy in 95% of patients. However, for treatment this arrhythmia with wide complexes QRS verapamil is contraindicated. Beside of, it should be taken in account that treatment of this type of cardiac arrhythmia cardiac glycosides are forbidden also. Verapamil and cardiac glycosides are contraindicated for termination of arrhythmia in patients with WPW syndrome and such disorders of cardiac rhythm as atrial fibrillation (flutter). For therapy of atrial fibrillation (flutter) in patients with WPW syndrome antiarrhythmic agents of agents of І A subclass (quinidine, procainamide, disopyramide, propafenone) and ІІІ class (amiodarone, sotalol) can be useful. For interruption of paroxysmal tachycardia in patients with syndrome preexitation antiarrhythmical preparations of plant origin (gilurytmal and allapinin) have high efficacy. Termination of paroxysmal tachycardia in patients with premature excitation of ventricles can be achieved after administration of antiarrhythmic agents of ІС subclass, in particular after using of propafenone and encainide. However, treatment with help these agents quite often bring about appearance of arrhythmogenic action. It is impossible using in preextation syndrome and cardiac arrhythmias drugs, which cause the acceleration of conductivity of nerve impulses in additional pathways (cardiac glycosides, β-blocker agents, for example propranolol). In patients with paroxysmal atrioventricular reciprocating (circular) tachycardia digitalis and calcium channel blockers should be avoided. Such agents as digoxin and verapamil in this arrhythmia can turn out to be dangerous in WPW syndrome, since they raise the conductivity through additional conductive pathways.
Effect of adamantane derivative on expression of biofilm-associated genes in methicillin-resistant Staphylococcus aureus
(Elsevier B.V, 2023) Humeniuk, Nataliia; Zelena, Liubov; Vrynchanu, Nina; Ishchenko, Liudmyla; Bukhtiarova, Tetiana; Korotkij, Yurii; Vazhnichaya, Elena; Важнича, Олена Митрофанівна
In the etiology of nosocomial infections, the leading role belongs to such microorganisms as Staphylococcus aureus. Insufficient effectiveness of antimicrobial chemotherapy and practical absence of drugs with an antibiofilm activity encourage the development of new remedies. The study presents results on antibiofilm activity of the adamantane derivative 1‐[4‐(1‐adamantyl)phenoxy]‐3‐(N‐benzyl,N‐dimethylamino)‐2‐propanol chloride (KVM‐97) against methicillin‐resistant S. aureus (MRSA) and the effect of this agent on the expression genes that provide regulatory and biosynthetic functions of biofilms. The ability of adamantane derivative to affect S. aureus biofilms was tested by microtiter dish biofilm formation assay. The effect of KVM‐97 on expression level of genes icaA, icaD, icaR, agrA, sarA, clfB, fib, fnbB, ebpS, and eno was detected by the real‐time PCR. The KVM‐97 inhibits the formation of S. aureus biofilms at 5.0 MIC by 95.1 % and at 0.5 MIC – by 22.4 %. Under the action of KVM‐97, destruction of the mature biofilms was not detected. It inhibits expression of the icaADBC operon and agrA gene, as well as stimulates a transcriptional activity of the icaR regulator. Subinhibitory concentrations of the KVM‐97 significantly inhibit the expression of clfB, fib, fnbB, ebpS, and eno, but does not change the sarA gene expression. Thus, 1‐[4‐(1‐adamantyl)phenoxy]‐3‐(N‐benzyl,N‐dimethylamino)‐2‐propanol chloride shows pronounced antibiofilm activity against MRSA at the early stages of the biofilm forming. This effect may be relating to influence on the expression of genes that regulate adhesion to the substrate and formation of S. aureus biofilms.
Ensuring and observing the principles of academic integrity is one of the priority areas of modern higher medical education
(Полтавський державний медичний університет, 2024) Hryshko, Yu. M.; Lutsenko, R. V.; Гришко, Юлія Михайлівна; Луценко, Руслан Володимирович
One of the most important and urgent tasks facing higher educational medical institutions of Ukraine and foreign countries today is the issue of ensuring and maintaining academic integrity, which is one of the priority areas of activity of the modern scientific and educational community. Recently, there has been an active discussion of certain provisions of the Law of Ukraine «On Higher Education», especially those issues related to the definition of academic freedom and information, the conduct of scientific research and the use of their results, taking into account the limitations established by law. Therefore, in order to prevent academic dishonesty, it is possible to recommend the establishment of independent organizations whose activities are aimed at resolving disputes in the field of academic integrity to protect the rights of students and teachers; for independent assessment of the level of knowledge of education seekers, it is necessary to develop and implement computer testing with automatic assessment of work. It is also advisable to use specialized software to detect plagiarism. Nowadays, regardless of the existing norms of laws, there is often a lack of effective procedures for evaluating scientific texts for the presence of various types of academic dishonesty. Abroad, in European and American universities, it is quite rare for students to resort to writing off, and scientists to change the results of research, as liability under the law is provided for this. Global trends in the fight against plagiarism are based on progressive «smart» technologies. Adherence to academic integrity is not only an important factor in ensuring the quality of higher education, but also an important criterion that determines what moral and ethical principles will be formed in the students of higher medical education during the years of their studies in higher educational institutions. Because precisely such components of academic integrity as justice, trust, respect, responsibility, honesty are at the same time universal human values and the key to the successful development of the state Одним із найбільш важливих і невідкладних завдань сьогодення, які стоять перед вищими навчальними медичними закладами України та зарубіжних країн, є питання забезпечення і дотримання академічної доброчесності, що є одним з пріоритетних напрямків діяльності сучасної науково-освітньої спільноти. Останнім часом ведеться активне обговорення певних положень Закону України «Про вищу освіту», особливо тих питань, які стосуються визначення академічної свободи та інформації, проведення наукових досліджень і використання їх результатів з урахуванням обмежень, встановлених законом. Отже, для запобігання академічної недоброчесності можна рекомендувати заснування незалежних організацій, діяльність яких спрямована на вирішення спорів у сфері академічної доброчесності для захисту прав здобувачів освіти і викладачів; для незалежного оцінювання рівня знань здобувачів освіти, необхідно розробляти та запроваджувати комп’ютерне тестування з автоматичним оцінюванням роботи. Також для виявлення плагіату доцільно використовувати спеціалізоване програмне забезпечення. В наш час, не зважаючи на існуючі норми законів, часто не вистачає ефективних процедур оцінюваннянаукових текстів на наявність різних видів академічної не доброчесності. За кордоном, в європейських та американських університетах, досить рідко студенти вдаються до списування, а науковці – до зміни результатівдосліджень, так як за це передбачена відповідальність перед законом. Світові тенденції боротьби із плагіатом спираються на прогресивні «розумні» технології. Дотримання академічної доброчесності є не тільки важливим фактором забезпечення якості вищої освіти, а ще й тим важливим критерієм, який визначає, які моральні і етичні принципи будуть сформовані у здобувачів вищої медичної освіти за роки їхнього навчання у вищих навчальних закладах. Тому що саме такі складники академічної доброчесності, як справедливість, довіра, повага, відповідальність, чесність є водночас і загальнолюдськими цінностями, і запорукою успішного розвитку держави.
Examinations Of Indian Patients Who Have Diabetes Mellitus
(Journal of Pharmaceutical Negative Results, India, 2023) Jha, Sahil Kumar ; Rauth, Upasona; Kovalev, S. V.; Deviatkina, N. M.; Ковальов, Сергій Володимирович; Дев'яткіна, Наталія Миколаївна
Blood glucose (or blood sugar) levels that are elevated in people with diabetes are chronic metabolic conditions that over time cause substantial harm to the heart, blood vessels, eyes, kidneys, and nerves. The most prevalent type of diabetes is type 2, which often affects adults, and develops whenever the body stops producing enough insulin or becomes resistant to it. Type 2 diabetes has been much more common over the last three decades in nations of all income levels. Diabetes type 1 is a chronic condition in which the pancreas produces little or no insulin by itself. It was previously referred to as juvenile diabetes or insulin-dependent diabetes. The availability of affordable medical care, particularly insulin, is essential for the survival of individuals who have diabetes. Diabetes mellitus, which is primarily defined by hyperglycemia, polyuria, and polyphagia, has developed into a serious and persistent metabolic condition as a consequence of a dynamic interactions of hereditary and environmental variables. Numerous diabetes problems might arise from uncontrolled high blood sugar. Long-term diabetes causes severe complications, some of which are fatal. All around the world, the prevalence of diabetes patients is increasing at epidemic rates. Annually, diabetes and related disorders consume a sizable percentage of the national health budget. The etiopathogenesis of the disease and the emergence of the outbreak are both influenced by a number of adverse outcomes. According to reports, diabetes, which has no known cure, can be managed by maintaining daily self-care, receiving good diabetes education, and making significant gains.The untreatable condition of diabetes may be managed by maintaining personality in everyday life, providing appropriate diabetes education, and making significant advancements in knowledge, attitudes, skills, and management. In this scientific report, we will have presented reports which included data on the subjects' fasting, postprandial, and glycated hemoglobin blood sugar levels, lipid profile, LFT, and RFT. The data results analyzed is in table form.

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