Differential drug correction cytokine and prostaglandin content in blood and gingival fluid in generalized periodontitis against the background of different responsiveness of the organization
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Дата
2023-09
Назва журналу
Номер ISSN
Назва тому
Видавець
Aluna Publishing
Анотація
The aim is to study the dynamics of prostaglandins and cytokines in the blood and gingival fluid against the background of differential drug correction in
patients with generalized periodontitis with different body reactivity.
Materials and methods: 216 people aged 45 between 55 years with a diagnosis of generalized periodontitis of II, III degree of severity, chronic course were
examined. Depending on the state of reactivity of the organism, the patients were divided into three groups: the first one consisted of people with normoreaction;
the second group included patients with hyperreaction; the third group was made up of people with hyporeaction. The patients underwent patch surgery after
the initial therapy. Initially, on the 1st, 2nd, 4th, 6th and 9th day after the operation, the content of prostaglandins (PG) E, E2, F2alpha and cytokines (IL-1β, IL-6,
TNF, IL-4) in the blood and gingival fluid was performed. Patients with impaired body reactivity were treated with the proposed differential drug correction of
cytokines and prostaglandins. Statistical processing of the obtained digital data was performed using the computer program Statistica 8.0.
Results: The proposed differential drug correction in patients with generalized periodontitis against the background of hyper- and hyporeactivity of the body
brings the content of IL-1β, IL-6, TNF, IL-4 to that of normal body reactivity, which ultimately restores the disturbed balance of pro- and anti-inflammatory
cytokines in the blood and gingival fluid. On the 9th day, the content of all proinflammatory cytokines in the main groups was normalized and was commensurate
with that of the body’s normal response (p>0.05). Differential drug correction led to normalization of the prostaglandin balance index on day 9 after flap
surgery (p>0.05), indicating the establishment of a normal balance of eicosanoids in the blood and approximating the values of pro- and anti-inflammatory
fractions of prostaglandins to those of normal body reactivity.
Conclusion: Correction of altered parameters in patients with generalized periodontitis accompanied by impaired (hyper- and hypo-) reactivity of the body
with bringing them to values that are typical for normoreactivity is considered to be a condition for optimizing mucosal wound healing after surgery and
further stabilization of periodontal tissues.
Опис
Ключові слова
periodontitis, reactivity of the organism, drug treatment, cytokines, prostaglandins
Бібліографічний опис
Differential drug correction cytokine and prostaglandin content in blood and gingival fluid in generalized periodontitis against the background of different responsiveness of the organization / Yu. Yarov, I. Tkachenko, P. Skripnikov, O. Pavlenkova, S. Pavlenko // Wiadomosci Lekarskie. – 2023. – Vol. LXXVI, issue. 9. – P. 2047–2053.