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A clinical case of persistent Lyme disease in a child
(2024) Pikul, K. V.; Ilchenko, V. I.; Prylutskyi, K. Yu.; Muravlova, O. V.; Shaienko, Z. O.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Прилуцький, Костянтин Юрійович; Муравльова, Оксана Василівна; Шаєнко, Златослава Олексіївна
Background. The relevance of the study is due to the frequent occurrence of Lyme disease (neuroborreliosis) in the spring-autumn period. Official record of Lyme disease in Ukraine has been conducted since 2000, although the first cases were identified in the 1990s. From 2001 to 2023, the incidence of Lyme borreliosis in Ukraine increased almost by 35 times. Materials and methods. The authors conducted a retrospective analysis of statistical data on Lyme borreliosis morbidity from 2000 to 2023 and the most common cases of infectious pathology in children during this period. As pediatric infectious disease specialists, the authors present a clinical case recently observed in the pediatric infectious unit in Poltava. Results. The diagnosis of Lyme borreliosis is made based on a characteristic clinical picture and a serological confirmation. The latter is crucial in the diagnosis of Lyme borreliosis and includes 2 stages. The first stage is the assessment of immunoglobulin M and G titers by the immunofluorescence assay (IFA). If the result is negative, further investigation is conducted within the first 30 days of symptoms onset by repeated IFA 4–6 weeks after the initial test. If the analysis is conducted ≥ 30 days after the onset of symptoms, further examinations are not carried out, and an alternative diagnosis should be suspected. In case of a doubtful or positive IFA result, the diagnosis is further confirmed by the Western blotting (the second stage). The authors present a case report of a 6-year-old girl M., hospitalized in the pediatric infectious unit of the CE “Municipal Clinical Hospital 1” (Poltava) in March 2023 with a diagnosis of Lyme disease (systemic tick-borne borreliosis), early disseminated stage, myalgia, arthralgia, subacute course, moderate severity. Acetonemic syndrome. Stage 1 deficiency anemia. Metabolic cardiomyopathy. Speech development delay. Conclusions. Therefore, it is crucial to recognize Lyme disease with a progressing or remitting disseminated form, as specific therapeutic approaches exist that are effective for this disabling condition.
A first clinical case report of West Nile Viral encephalitis in Poltava region of Ukraine
(Aluna Publishing, 2020) Kotelevska, T. M.; Pryimenko, N. O.; Dubynska, H. M.; Iziumska, O. M.; Koval, T. I.; Pikul, K. V.; Purdenko, T. Y.; Котелевська, Тетяна Михайлівна; Прийменко, Наталія Олегівна; Дубинська, Галина Михайлівна; Ізюмська, Олена Михайлівна; Коваль, Тетяна Ігорівна; Пікуль, Катерина Вікторівна
West Nile Fever (WNF) is the most common arbovirus infection caused by West Nile Virus (WNV), which has been responsible for numerous epidemic outbreaks of disease among humans, birds and horses on all continents, with the exception of Antarctica, over the past two decades. On the territory of Ukraine, the earliest reports of cases of WNV circulation in humans and birds relate to the 70s of the XX century. In Poltava region WNF was first registered in 2011. Though the epidemiological and clinical patterns of WNF in Ukraine and Poltava region remain understudied, primarily due to the lack of alertness of practitioners to the problem of WNF and to broader access to laboratory diagnosis of the disease. The first clinical case of West Nile Viral encephalitis, registered on the territory of Poltava region, has been given and analyzed.
Childrens exanthematous infections
(Полтавський державний медичний університет, 2022) Ilchenko, V. I.; Pikul, K. V.; Prylutskiy, K. Yu.; Dudnikova, A. M.; Ільченко, Валентина Іванівна; Пікуль, Катерина Вікторівна; Прилуцький, Костянтин Юрійович; Дуднікова, Антоніна Миколаївна
Навчально-методичний посібник підготовлений співробітниками кафедри ендокринології з дитячими інфекційними хворобами (в.о. зав. кафедри доцент О.В. Муравльова) ПДМУ, доц., к.мед.н. В.І. Ільченко, доц., к.мед.н. К.В. Пікуль, к.мед.н. К.Ю. Прилуцьким, асистентом А.М. Дудніковою.
Comparative analysis of clinical and laboratory characteristics of measles in vaccinated and unvaccinated children in the Poltava region (Ukraine)
(Aluna Publishing, 2022) Ilchenko, V. I. ; Syzova, L. M.; Pikul, K. V.; Dvornik, I. L.; Muravleva, O. V.; Ільченко, Валентина Іванівна; Сизова, Людмила Михайлівна; Пікуль, Катерина Вікторівна; Дворник, Ірина Леонідівна; Муравльова, Оксана Василівна
The aim: To study the clinical and laboratory characteristics of measles, as well as to compare the course of this disease in vaccinated and unvaccinated children in the Poltava region (Ukraine). Materials and methods: 104 inpatients with measles were examined: vaccinated (n=27) and unvaccinated (n=77). The patient examination program included: assessment of complaints and anamnestic data obtained by questioning (during admission to hospital treatment, during treatment and after discharge) and detailed analysis of medical records (Form № 003/у), physical examination, general clinical study of peripheral blood. Statistical processing of the study results was carried out by methods of variation statistics using the program «SPSS 17.0». Results: The clinical and laboratory picture of measles in the examined patients is typical for this disease. Measles vaccinated children are significantly less likely to have fever (р=0.001) and Koplik’s spots (χ2 =3.80, р=0.051), the duration of fever (р=0.001), cough (р=0.000), and the length of hospital stay (р=0.000), as well as 3.0 times less often leukopenia is detected (р=0.043) and 2.0 times less often − acceleration of ESR (р=0.023). Conclusions: The obtained data raise the question of expanding the explanatory work on the importance of a full course of preventive vaccination among children, as well as increasing the volume of public procurement of necessary drugs to increase public access to free vaccination.
Condition and optimisation of children athletes protein-energy metabolism
(Республиканское унитарное предприятие «Издательский дом «Белорусская наука», 2017) Shkurupiy, D. A.; Pikul, K. V.; Kushnereva, T. V.; Prilutsky, K. Yu.; Шкурупій, Дмитро Анатолійович; Пікуль, Катерина Вікторівна; Кушнерева, Тетяна Вікторівна; Прилуцький, Костянтин Юрійович
The purpose of the study is to evaluate the effectiveness of the use of additional nutritional components in the diet of children of athletes in order to ensure an adequate balance of the protein-energy component against the background of increased energy and formative consumption, which is associated with training and competitive activities.
Current aspects of scientific research within the student scientific society
(2024) Pikul, K. V.; Shpetnyi, O. А.; Mykhailova, A. V.; Пікуль, Катерина Вікторівна; Шпетний, Олександр Андрійович; Михайлова, А. В.
At the Department of Endocrinology with Children's Infectious Diseases of the Poltava State Medical University within the framework of the student scientific society under the leadership of teachers, a research work was conducted on the topic: "Psychological features of students of higher education of the State Medical University during martial law." A questionnaire was conducted, which made it possible to assess the psychological state of those seeking higher education. The conducted correlational analysis based on the results of the surveys proved the following: - the absence of a reliable relationship between manifestations of anxiety, responsibility and the locus of subjective control. The researchers also noted the connection between the professional activity of future medical workers and the constant emotional interaction with patients, the monotony of work, and the need to solve other people's problems. Another question was considered: humor as a protective reaction to stress. The work is of great importance not only from the psychological and scientific standpoint of the study of humor. The performed analysis is aimed at investigating the validity of the use of existing methods in order to study humor precisely as a mechanism of struggle in stressful situations. The application of elements of research work in the educational and methodological process of the clinical departments of the university increases the effectiveness of the training of students of higher education, promotes the implementation of the latest methods, and also makes it possible to use classroom hours more efficiently and rationally. The time spent by students of higher education in the clinic in this way leaves a very positive effect, stimulates future doctors to study, acquire new knowledge and skills, and also motivates them to preserve their own health. A significant effect of self-education and self-organization of higher education seekers in today's conditions also contributes to the improvement of the professional level of scientific and pedagogical workers, which allows to achieve quality education. The following are important tasks for the work of the acquirers: to involve in full participation; teach participants of group interaction to make balanced collective decisions; be responsible for every action or decision; - to be able to defend one's point of view or position in life.
Current issues of pedagogy at the international medical faculty
(Полтава : Астрая, 2024) Pikul, K. V.; Shaienko, Z. O.; Ilchenko, V. I.; Muravlova, O. V.; Prylutskyi, K. Yu.; Пікуль, Катерина Вікторівна; Шаєнко, Златослава Олексіївна; Ільченко, Валентина Іванівна; Муравльова, Оксана Василівна; Прилуцький, Костянтин Юрійович
Процеси європейської інтеграції охоплюють дедалі більше сфер життєдіяльності нашої держави. Принцип свідомості, самостійності та активності з інтенсифікацією самостійної роботи здобувачів, відпрацювання практичних навичок на тренажерах та муляжах. Ми чітко окреслюємо реалії входження у європейський науковий і освітній простір задля підвищення професійного рівня наших випускників до конкурентоспроможного працевлаштування на європейському ринку праці, щоб одержані знання й уміння могли бути реалізованими. Сучасне молоде покоління суттєво відрізняється від ровесників минулого століття, оскільки його становлення та виховання відбуваються в період руйнації старих цінностей та формування нових перспектив, про що має пам ’ятати викладач.
Current status of polio vaccination in children
(Громадська організація «Львівська медична спільнота», 2020) Kushnereva, T. V.; Pikul, K. V.; Prylutskyi, K. Iu.; Chebotar, O. V.; Кушнерева, Тетяна Вікторівна; Пікуль, Катерина Вікторівна; Прилуцький, Костянтин Юрійович; Чеботар, Олександр Віталійович
The Polio Eradication Initiative for 2019-2023 contains non-epidemic, poliovirus-infected high-risk countries, including Ukraine, India, Ethiopia, Uganda and other African countries. The most important tasks facing Ukraine are to help strengthen the health and immunization system against polio, stop the spread of all wild polioviruses, all outbreaks of circulating polioviruses of the vaccine origin and eliminate the risk of their occurrence in the future.
Diabetes therapy in wartime conditions
(Scientific Publishing Center “Sci-conf.com.ua”, 2023) Muravleva, O. V.; Pikul, K. V.; Shaienko, Z. O.; Муравльова, Оксана Василівна; Пікуль, Катерина Вікторівна; Шаєнко, Златослава Олексіївна
The article highlights the most urgent problem of endocrinology - diabetes mellitus (DM), which is spreading at a catastrophic rate, becoming a real epidemic of the XXI century. Metformin is a hypoglycemic drug that has proven its effectiveness in the treatment of type 2 diabetes for many years. Therefore, it is metformin that is stable in the choice of the drug of the first line of glucose-lowering therapy. Type 2 diabetes is one of the most common diseases characterized by metabolic disorders as a result of many pathophysiological processes. The leading pathophysiological disorder of type 2 diabetes is insulin resistance of muscle and adipose tissue together with pancreatic β-cell dysfunction. Further processes take place in adipose tissue, organs of the gastrointestinal tract, α-cells of the pancreas, and kidneys. All this leads to the development of chronic hyperglycemia.
Diphtheria: current public health challenge in ukraine and worldwide (literature review)
(Aluna Publishing, 2021) Pikul, K. V.; Syzova, L. M.; Il'chenko, V. I.; Zvyagolska, I. M.; Пікуль, Катерина Вікторівна; Сизова, Людмила Михайлівна; Ільченко, Валентина Іванівна; Звягольська, Ірина Миколаївна
The relevance of the topic is determined by the priority and importance of preserving the health of Ukrainian population by improving the current rate of vaccinated individuals against diphtheria. Diphtheria is assigned to one of the dangerous and life-threatening diseases in humans. Immunization is the only means of creating a favorable epidemic situation. Ensuring of non-susceptibility of people to this infection prevents the incidence and spread of diphtheria in the population.
HIV/AIDS in Ukraine during martial law
(Полтавський державний медичний університет, 2024-10-30) Pikul, K. V.; Ilchenko, V. I.; Muravlova, O. V.; Shaienko, Z. O.; Kiziun, M. A.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Муравльова, Оксана Василівна; Шаєнко, Златослава Олексіївна; Кізюн, Маргарита Андріївна
There are several million HIV-infected children worldwide. In Ukraine, 99% of infants are infected with HIV through perinatal transmission. A rapid progression of the spread has been noted - 15-20% of cases result in AIDS or death by the age of four. In cases of slower progression, 75-80% have an average survival rate of 8-9.5 years. Unfortunately, scientists report that not only changes in the environment, but also social upheavals and war indirectly lead to an increase in infectious diseases.
Infectious diseases of the digestive system in children
(Полтавський державний медичний університет, 2020) Pikul, K. V.; Ilchenko, V. I.; Chebotar, O. V.; Prylutskiy, K. Yu.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Чеботар, Олександр Віталійович; Прилуцький, Костянтин Юрійович
The educational manual is compiled according to a typical curriculum and a program for the preparation of foreign students of medical institutions of higher education for the cycle "Children's Infectious Diseases". This teaching manual is written in English and is devoted to the issues of etiology, epidemiology, clinics and differential diagnostics of the most common infectious diseases of children, diagnostic algorithms and therapies are given in accordance with the treatment protocols approved by the Ministry of Health of Ukraine. The titles of the sections were chosen by the authors in accordance withthe thematic plan for thepreparation of foreign students of medical institutions of highereducation. The manual contains questions for self-control, tests, tasks and analysis of children's diseaserecords that were treated at the children's department for a deeper assimilation of the material. Навчальний посібник складений згідно з типовим навчальним планом та програмою для підготовки іноземних студентів медичних закладів вищої освіти для циклу «Дитячі інфекційні хвороби». Цей навчально-методичний посібник написаний англійською мовою і присвячений питанням етіології, епідеміології, клініки та диференційної діагностики найбільш частих дитячих інфекційних хвороб, наведені алгоритми діагностики та терапії, згідно з протоколами лікування, що затверджені МОЗ України. Назви розділів автори підібрали у відповідності з тематичним планом для підготовки іноземних студентів медичних закладів вищої освіти. Посібник містить запитання для самоконтролю, тести, задачі та розбір історій хвороб дітей, що лікувались у дитячому відділенні ПОКІЛ для більш глибокого засвоєння матеріалу.
Infectious mononucleosis during the war and covid infection pandemic in Ukraine
(Aluna Publishing, 2023) Pikul, K. V.; Ilchenko, V. I.; Sуzova, L. M.; Muravlоva, O. V.; Dvornyk, I. L.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Сизова, Людмила Михайлівна; Муравльова, Оксана Василівна; Дворник, Ірина Леонідівна
Currently, the issue of infectious mononucleosis is relevant due to the following main factors: the rising incidence of morbidity in Ukraine over the past 3 years, the great variability of the clinical course of the disease and the complexity of specific diagnostics, which leads to a large percentage of diagnostic errors, the general infection with the Epstein-Barr virus (EBV), which can affect the immune system. Antibodies to EBV are detected in 15% of children under 1 year of age and 90% of adults. All this is caused by a large number of risk factors: migration of the population from temporarily occupied territories, overcrowding of people in places of refuge from the war, changes in the quality of food, humanitarian difficulties, the action of chemicals, stress and immunosuppression. The war led to an increase in viral etiology and an increase in the share of children with secondary bacterial complications, a decrease in the percentage of vaccinated persons according to the vaccination calendar. We know that after such childhood infections as measles and chicken pox there is lifelong immunity, then infectious mononucleosis is a rather serious disease that affects the immune system, epitheliocytes of blood vessels, can turn into a chronic course and complicate the quality of life, causing concern to doctors.
Intensive care in the clinics of childhood infectious diseases
(Українська медична стоматологічна академія, 2020) Pikul, K. V.; Ilchenko, V. I.; Prylutzkiy, К. Yu.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Прилуцький, Костянтин Юрійович
Навчально-методичний посібник складений згідно з типовим навчальним планом та програмою для підготовки іноземних студентів медичних закладів вищої освіти для циклу «Дитячі інфекційні хвороби». Цей навчально-методичний посібник написаний англійською мовою і присвячений питанням етіології, епідеміології, клініки та диференційної діагностики найбільш частих дитячих інфекційних хвороб, наведені алгоритми діагностики та терапії, згідно з протоколами лікування, що затверджені МОЗ України. Назви розділів автори підібрали у відповідності з тематичним планом для підготовки іноземних студентів медичних закладів вищої освіти. Посібник містить запитання для самоконтролю, тести, задачі та розбір історій хвороб дітей, що лікувались у дитячому відділенні ПОКІЛ для більш глибокого засвоєння матеріалу.
Measles in Ukrain: current challenges
(2019) Pikul, K. V.; Prylutskyi, K. Y.; Chebotar, O. V.; Пикуль, Екатерина Викторовна; Прилуцкий, Константин Юрьевич; Чеботар, Александр Витальевич; Пікуль, Катерина Вікторівна; Прилуцький, Костянтин Юрійович; Чеботар, Олександр Віталійович
Currently, the significance of the problem for measles in Ukraine is attributed to the increased incidence of outbreaks of the disease among children and teenagers with fatal cases. The findings of the analysis of the nationwide coverage for measles vaccination in 2012-2017 are unfavorable: in 2008 the rate of vaccinated individuals constituted 95%, while in 2012, 2013 and 2016 it was 79%, 49% and 45,5%, respectively. Estimates of measles incidence in Ukraine in 2012 revealed 12746 measles cases with the intensive rate of 27.9 per 100 000 of the population, indicating about a high epidemic rise of measles. During the in-between epidemic period, particularly in 2016, only sporadic 102 cases were reveled. In 2018, during the first two months 1248 measles cases were registered with measles-related deaths of 8 people: 6 deaths of children among which 1 death of a newborn with congenital measles and 1death of a baby aged 5 months.
Measles in Ukrain: current challenges
(Сollective monograph, 2019) Pikul, K. V.; Syzova, L. M.; Пікуль, Катерина Вікторівна; Сизова, Людмила Михайлівна; Пикуль, Екатерина Викторовна; Сизова, Людмила Михайловна
Modern approach to the problem of pertussis
(Wydawnictwo Aluna, 2019) Ilchenko, V. I.; Sizova, L. M.; Tanianska, S. M.; Nesina, I. M.; Pikul, K. V.; Ільченко, Валентина Іванівна; Сизова, Людмила Михайлівна; Танянська, Світлана Михайлівна; Несіна, Інна Миколаївна; Пікуль, Катерина Вікторівна; Ильченко, Валентина Ивановна; Сизова, Людмила Михайловна; Танянская, Светлана Михайловна; Несина, Инна Николаевна; Пикуль, Екатерина Викторовна
Introduction: Recently, there has been a tendency to increase the incidence of pertussis in many countries of the world and this disease in these countries is among 10 most serious causes of death in young children. The aim of the work − is to analyze specialized scientific literature for generalization of data and present a modern look at questions of etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment and immunoprophylaxis of pertussis. Materials and methods: Available scientific sources over the past years, devoted to the problem of pertussis are studied by the methods of overview, system and content analysis. Review and conclusions: The main questions of pertussis are outlined. Timely diagnosis, treatment and immunoprophylaxis allow adjusting the actions of doctors to solve the issues of the decrease of the incidence of pertussis. This is greatly helped by modern guidelines for the management of patients with this pathology.
New challenges in the morbidity of children from nitrate-polluted territories during wartime
(Riga, Latvia : Izdevnieciba «Baltija Publishing», 2022) Pikul, K. V.; Ilchenko, V. I.; Muravleva, O. V.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Муравльова, Оксана Василівна
The topicality is determined bypriority and importance of researches that have preventive referral directed on provision of harmonious growth and early childhood development, children’s resistance to the infection’s effects and other unfavorable external factors. There are problems about the role of permanent nitrate load in the formation of children health issues, especially children who live in the area with high nitrate levels in drinking well water.
New challenges of distance teaching at the international medical faculty during the war and coronavirus pandemic in Ukraine
(Полтавський державний медичний університет, 2024) Pikul, K. V.; Ilchenko, V. I.; Shaienko, Z. O.; Muravlоva, O. V.; Prylutskyi, K. Y.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Шаєнко, Златослава Олексіївна; Муравльова, Оксана Василівна; Прилуцький, Костянтин Юрійович
The aim of this work is to address specific challenges related to the organization and future prospects of distance teaching in medical higher education institutions, especially pertinent amidst the current military situation in Ukraine. Materials and methods. In our analysis, we reviewed relevant experiences and documentation, considering the participation of medical students in higher education. The data analysis on student’s performance and engagement in online courses to assess the effectiveness of current distance teaching methods was performed. Results and discussion. The education of medical professionals at international faculties holds significant national importance, contributing to addressing various societal challenges and enhancing Ukraine's educational reputation. However, recent events such as the COVID-19 pandemic and martial law have posed new challenges for distance teaching practices in pedagogy. Ii is crucial for educators who work with international medical students to possess high levels of professionalism and moral integrity. Across the globe, simulation technologies are increasingly employed in medical training, offering innovative methods for preparing highly skilled medical personnel. One such technology is the "virtual patient," which allows learners to engage in realistic clinical scenarios, make diagnostic and treatment decisions, and understand the consequences of their actions without compromising patient safety. The development of communication and language skills among future medical professionals remains a pressing concern within higher education institutions. Utilizing technological storytelling methods to illustrate the journeys of successful specialists can provide valuable insights and inspiration for students. In the context of distance learning, maintaining prompt feedback channels between students and departmental teachers is essential for effective learning outcomes. Conclusion. Practical application of innovative methodological approaches provide with opportunity for teachers of medical higher education institutions to implement and improve the novel methods of work, to increase the effectiveness of the educational process and the level of knowledge of students of the international faculty. Innovative distance learning technologies stimulate the teacher's work, increase his/her professional level, since the organization of the educational process requires preparation for each class, constant pedagogical research, development and use of additional new materials, study of innovative technologies.
Pediatric infectious diseases in family doctor’s practic
(2019) Pikul, K. V.; Ilchenko, V. I. ; Prylutskiy, K. Yu.; Пікуль, Катерина Вікторівна; Ільченко, Валентина Іванівна; Прилуцький, Костянтин Юрійович
Навчально-методичний посібник складений згідно з типовим навчальним планом та програмою для підготовки іноземних студентів медичних закладів вищої освіти для циклу «Дитячі інфекційні хвороби». Цей навчально-методичний посібник написаний англійською мовою і присвячений питанням етіології, епідеміології, клініки та диференційної діагностики найбільш частих дитячих інфекційних хвороб, наведені алгоритми діагностики та терапії, згідно з протоколами лікування, що затверджені МОЗ України. Назви розділів автори підібрали у відповідності з тематичним планом для підготовки іноземних студентів медичних закладів вищої освіти. Посібник містить запитання для самоконтролю, тести, задачі та розбір історій хвороб дітей, що лікувались у дитячому відділенні ПОКІЛ для більш глибокого засвоєння матеріалу; The teaching manual is compiled according to a typical curriculum and a program for the preparation of foreign students of medical institutions of higher education for the cycle "Children's Infectious Diseases". This teaching manual is written in English and is devoted to the issues of etiology, epidemiology, clinics and differential diagnostics of the most common infectious diseases of children, diagnostic algorithms and therapies are given in accordance with the treatment protocols approved by the Ministry of Health of Ukraine. The titles of the sections were chosen by the authors in accordance withthe thematic plan for thepreparation of foreign students of medical institutions of highereducation. The manual contains questions for self-control, tests, tasks and analysis of children's diseaserecords that were treated at the children's department for a deeper assimilation of the material.

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